Positional information in neural map development: Lessons from the olfactory system

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Positional information is fundamental in development. Although molecular gradients are thought to represent positional information in various systems, the molecular logic used to interpret these gradients remains controversial. In the nervous system, sensory maps are formed in the brain based on gradients of axon guidance molecules. However, it remains unclear how axons find their targets based on relative, not absolute, expression levels of axon guidance receptors. No model solely based on axon-target interactions explains this point. Recent studies in the olfactory system suggested that the neural map formation requires axon-axon interactions, which is known as axon sorting. This review discusses how axon-axon and axon-target interactions interpret molecular gradients and determine the axonal projection sites in neural map formation.

Original languageEnglish
Pages (from-to)358-365
Number of pages8
JournalDevelopment Growth and Differentiation
Volume54
Issue number3
DOIs
Publication statusPublished - Apr 1 2012
Externally publishedYes

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Axons
Nervous System
Brain

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

Positional information in neural map development : Lessons from the olfactory system. / Imai, Takeshi.

In: Development Growth and Differentiation, Vol. 54, No. 3, 01.04.2012, p. 358-365.

Research output: Contribution to journalReview article

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