Angiography in a 35-year-old man, with a history of transient ischaemic attacks and a convulsive seizure, showed bilateral stenosis of the distal internal carotid arteries, and positron-emission tomography (PET) revealed inadequate blood flow in the right frontal lobe (decreased blood flow, increased oxygen extraction). A lupus anticoagulant and an elevated anticardiolipin antibody concentration were detected in serum. The patient's condition progressed from ischaemia to infarction resulting in the diagnosis of antiphospholipid syndrome and steroid and antiplatelet treatment resulted in an improved neurologic state and laboratory findings. PET showed better correlation with clinical features than carotid angiography in this case of antiphospholipid syndrome leading to stroke.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging