Possibilities in Germ Cell Research: An Engineering Insight

Fereshteh Esfandiari, Omid Mashinchian, Mohammad Kazemi Ashtiani, Mohammad Hossein Ghanian, Katsuhiko Hayashi, Amir Ata Saei, Morteza Mahmoudi, Hossein Baharvand

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Germ cells (GCs) are responsible for fertility and disruptions in their development or function cause infertility. However, current knowledge about the diverse mechanisms involved in GC development and function is still in its infancy. This is mainly because there are low numbers of GCs, especially during embryonic development. A deeper understanding of GCs would enhance our ability to produce them from stem cells. In addition, such information would enable the production of healthy gametes for infertile couples. In this regard, pluripotent stem cells (PSCs) demonstrated a promising ability to produce GCs in vitro. In this review, we highlight recent advances in the field of tissue engineering that suggest novel strategies to enhance GC research. Advanced therapies for infertility require developing systems for the efficient production of germ cells from stem cells in the laboratory.We discuss recent advances and challenges of germ cell research.Here, we propose engineering approaches for designing an artificial niche for germ cell development in vitro.Novel platforms are demonstrated for the epigenetic analysis of germ cells.Innovative approaches are detailed for the efficient production of germ cells from pluripotent stem cells.

Original languageEnglish
Pages (from-to)735-746
Number of pages12
JournalTrends in biotechnology
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 2015

Fingerprint

Engineering research
Germ Cells
Cells
Stem cells
Research
Pluripotent Stem Cells
Tissue engineering
Infertility
Stem Cells
Tissue Engineering
Epigenomics
Embryonic Development
Fertility

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Cite this

Esfandiari, F., Mashinchian, O., Ashtiani, M. K., Ghanian, M. H., Hayashi, K., Saei, A. A., ... Baharvand, H. (2015). Possibilities in Germ Cell Research: An Engineering Insight. Trends in biotechnology, 33(12), 735-746. https://doi.org/10.1016/j.tibtech.2015.09.004

Possibilities in Germ Cell Research : An Engineering Insight. / Esfandiari, Fereshteh; Mashinchian, Omid; Ashtiani, Mohammad Kazemi; Ghanian, Mohammad Hossein; Hayashi, Katsuhiko; Saei, Amir Ata; Mahmoudi, Morteza; Baharvand, Hossein.

In: Trends in biotechnology, Vol. 33, No. 12, 12.2015, p. 735-746.

Research output: Contribution to journalReview article

Esfandiari, F, Mashinchian, O, Ashtiani, MK, Ghanian, MH, Hayashi, K, Saei, AA, Mahmoudi, M & Baharvand, H 2015, 'Possibilities in Germ Cell Research: An Engineering Insight', Trends in biotechnology, vol. 33, no. 12, pp. 735-746. https://doi.org/10.1016/j.tibtech.2015.09.004
Esfandiari F, Mashinchian O, Ashtiani MK, Ghanian MH, Hayashi K, Saei AA et al. Possibilities in Germ Cell Research: An Engineering Insight. Trends in biotechnology. 2015 Dec;33(12):735-746. https://doi.org/10.1016/j.tibtech.2015.09.004
Esfandiari, Fereshteh ; Mashinchian, Omid ; Ashtiani, Mohammad Kazemi ; Ghanian, Mohammad Hossein ; Hayashi, Katsuhiko ; Saei, Amir Ata ; Mahmoudi, Morteza ; Baharvand, Hossein. / Possibilities in Germ Cell Research : An Engineering Insight. In: Trends in biotechnology. 2015 ; Vol. 33, No. 12. pp. 735-746.
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