TY - JOUR
T1 - Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese
AU - Torisu, Takehiro
AU - Takata, Yutaka
AU - Ansai, Toshihiro
AU - Matsumoto, Takayuki
AU - Sonoki, Kazuo
AU - Soh, Inho
AU - Awano, Shuji
AU - Yoshida, Akihiro
AU - Hamasaki, Tomoko
AU - Kagiyama, Shuntaro
AU - Nakamichi, Ikuo
AU - Ohsumi, Tomoko
AU - Toyoshima, Kuniaki
AU - Nishihara, Tatsuji
AU - Iida, Mitsuo
AU - Takehara, Tadamichi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.
AB - Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.
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U2 - 10.5551/jat.943
DO - 10.5551/jat.943
M3 - Article
C2 - 19729867
AN - SCOPUS:73249136275
SN - 1340-3478
VL - 16
SP - 691
EP - 697
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
IS - 5
ER -