Possible binding sites for inositol 1,4,5-trisphosphate in macrophages

Toyohiro Ishimatsu, Yuichi Kimura, Tetsuro Ikebe, Koji Yamaguchi, Toshitaka Koga, Masato Hirata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We reported that an arylazide derivative of inositol 1,4,5-trisphosphate (InsP3) caused irreversible InsP3-induced Ca2+ release from saponin-permeabilized macrophages after photoirradiation(1). To determine the specific receptors for InsP3, presumably present on the endoplastic reticulum, we synthesized isotope-labeled arylazide derivatives of InsP3; InsP3 was coupled with p-azidobenzoyl [3h]β -alanine InsP3-[3h]ABβ A ) or p-[125i]azidosalicyl β-alanine (InsP3-[125I]ASβ A). We report here that three proteins may be associated with the Ca2+ releasing mechanism, in photoirradiated saponin-permeabilized macrophages and in the microsomal fraction.

Original languageEnglish
Pages (from-to)1173-1180
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume155
Issue number3
DOIs
Publication statusPublished - Sep 30 1988

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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