Possible chemotherapy of muscular dystrophy caused by nonsense mutation

Masataka Shiozuka, Masayuki Arakawa, Ryoichi Matsuda

Research output: Contribution to journalArticle

Abstract

Gentamicin, an aminoglycoside antibiotics which causes read-through of premature termination codon during translation, has been used to rescue genetic diseases caused by nonsense mutation. Its strong side effects, however, has always threaten patients. In order to utilize other antibiotics with less side effects than gentamicin, we have shown that negamycin, a dipeptide antibiotics with read-through activity in prokaryotes, restored dystrophin in skeletal and cardiac muscles of mdx mouse, an animalumodel for Duchenne type muscular dystrophy caused by nonsens mutation. To avoid miscoding and emerging resistant bacteria for these read-through antibiotics, further drug design and high throughput screening of gentamicin- or negamycin-related molecules will be needed.

Original languageEnglish
Pages (from-to)908-910
Number of pages3
JournalClinical Neurology
Volume44
Issue number11
Publication statusPublished - Nov 1 2004
Externally publishedYes

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Muscular Dystrophies
Nonsense Codon
Gentamicins
Anti-Bacterial Agents
Drug Therapy
Inbred mdx Mouse
Dystrophin
Inborn Genetic Diseases
Duchenne Muscular Dystrophy
Dipeptides
Drug Design
Aminoglycosides
Myocardium
Skeletal Muscle
Bacteria
Mutation
negamycin

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Possible chemotherapy of muscular dystrophy caused by nonsense mutation. / Shiozuka, Masataka; Arakawa, Masayuki; Matsuda, Ryoichi.

In: Clinical Neurology, Vol. 44, No. 11, 01.11.2004, p. 908-910.

Research output: Contribution to journalArticle

Shiozuka, M, Arakawa, M & Matsuda, R 2004, 'Possible chemotherapy of muscular dystrophy caused by nonsense mutation', Clinical Neurology, vol. 44, no. 11, pp. 908-910.
Shiozuka, Masataka ; Arakawa, Masayuki ; Matsuda, Ryoichi. / Possible chemotherapy of muscular dystrophy caused by nonsense mutation. In: Clinical Neurology. 2004 ; Vol. 44, No. 11. pp. 908-910.
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