Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia

Tokiko Inoue; Arinobu Tojo; Daisuke Tsuchimoto; Shin Ichiro Okamoto; Hiromi Ogura; Kenzaburo Tani; Keiya Ozawa; Masabumi Shibuya; Shigetaka Asano

Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia

Tokiko Inoue, Arinobu Tojo, Daisuke Tsuchimoto, Shin Ichiro Okamoto, Hiromi Ogura, Kenzaburo Tani, Keiya Ozawa, Masabumi Shibuya, Shigetaka Asano

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Twenty six patients with Philadelphia chromosome (Ph₁) positive chronic myelogenous leukemia (CML) treated with IFN-α were classified on the basis of the fusion pattern of BCR/ABL chimeric mRNA determined by a reverse-transcriptase-polymerase chain reaction (RT-PCR) method. The relationship between the fusion pattern of BCR/ABL mRNA and the clinical outcome was also analysed. Twelve patients showed M-bcr exon 3/ABL exon 2 (B3/A2) chimeric mRNA and nine had M-bcr exon 2/ABL exon 2 (B2/A2) mRNA. Eleven of the 12 patients with B3/A2 achieved complete hematological response with IFN-α therapy, as did three of the nine patients with B2/A2. The mean duration to blastic crisis was significantly longer in the B3/A2 patients (mean 52.4 months) than in the B2/A2 patients (mean 26.2 months) (p<0.01). These results suggest that the fusion pattern of BCR/ABL mRNA may affect the therapeutic response to IFN-α and clinical outcome in CML patients.

Original language	English
Pages (from-to)	948-951
Number of pages	4
Journal	Leukemia
Volume	6
Issue number	9
Publication status	Published - Sept 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

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title = "Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia",

abstract = "Twenty six patients with Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) treated with IFN-α were classified on the basis of the fusion pattern of BCR/ABL chimeric mRNA determined by a reverse-transcriptase-polymerase chain reaction (RT-PCR) method. The relationship between the fusion pattern of BCR/ABL mRNA and the clinical outcome was also analysed. Twelve patients showed M-bcr exon 3/ABL exon 2 (B3/A2) chimeric mRNA and nine had M-bcr exon 2/ABL exon 2 (B2/A2) mRNA. Eleven of the 12 patients with B3/A2 achieved complete hematological response with IFN-α therapy, as did three of the nine patients with B2/A2. The mean duration to blastic crisis was significantly longer in the B3/A2 patients (mean 52.4 months) than in the B2/A2 patients (mean 26.2 months) (p<0.01). These results suggest that the fusion pattern of BCR/ABL mRNA may affect the therapeutic response to IFN-α and clinical outcome in CML patients.",

author = "Tokiko Inoue and Arinobu Tojo and Daisuke Tsuchimoto and Okamoto, {Shin Ichiro} and Hiromi Ogura and Kenzaburo Tani and Keiya Ozawa and Masabumi Shibuya and Shigetaka Asano",

year = "1992",

month = sep,

language = "English",

volume = "6",

pages = "948--951",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia

AU - Inoue, Tokiko

AU - Tojo, Arinobu

AU - Tsuchimoto, Daisuke

AU - Okamoto, Shin Ichiro

AU - Ogura, Hiromi

AU - Tani, Kenzaburo

AU - Ozawa, Keiya

AU - Shibuya, Masabumi

AU - Asano, Shigetaka

PY - 1992/9

Y1 - 1992/9

N2 - Twenty six patients with Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) treated with IFN-α were classified on the basis of the fusion pattern of BCR/ABL chimeric mRNA determined by a reverse-transcriptase-polymerase chain reaction (RT-PCR) method. The relationship between the fusion pattern of BCR/ABL mRNA and the clinical outcome was also analysed. Twelve patients showed M-bcr exon 3/ABL exon 2 (B3/A2) chimeric mRNA and nine had M-bcr exon 2/ABL exon 2 (B2/A2) mRNA. Eleven of the 12 patients with B3/A2 achieved complete hematological response with IFN-α therapy, as did three of the nine patients with B2/A2. The mean duration to blastic crisis was significantly longer in the B3/A2 patients (mean 52.4 months) than in the B2/A2 patients (mean 26.2 months) (p<0.01). These results suggest that the fusion pattern of BCR/ABL mRNA may affect the therapeutic response to IFN-α and clinical outcome in CML patients.

AB - Twenty six patients with Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) treated with IFN-α were classified on the basis of the fusion pattern of BCR/ABL chimeric mRNA determined by a reverse-transcriptase-polymerase chain reaction (RT-PCR) method. The relationship between the fusion pattern of BCR/ABL mRNA and the clinical outcome was also analysed. Twelve patients showed M-bcr exon 3/ABL exon 2 (B3/A2) chimeric mRNA and nine had M-bcr exon 2/ABL exon 2 (B2/A2) mRNA. Eleven of the 12 patients with B3/A2 achieved complete hematological response with IFN-α therapy, as did three of the nine patients with B2/A2. The mean duration to blastic crisis was significantly longer in the B3/A2 patients (mean 52.4 months) than in the B2/A2 patients (mean 26.2 months) (p<0.01). These results suggest that the fusion pattern of BCR/ABL mRNA may affect the therapeutic response to IFN-α and clinical outcome in CML patients.

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M3 - Article

C2 - 1518306

AN - SCOPUS:0026688329

SN - 0887-6924

VL - 6

SP - 948

EP - 951

JO - Leukemia

JF - Leukemia

IS - 9

ER -

Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to α-interferon in chronic myelogenous leukemia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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