Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar

Merina Akhter, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kou Matsuo, Haruyoshi Yamaza, Hiroko Wada, Jun Ya Honda, Xie Ming, Hidetaka Sakai

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31 Citations (Scopus)


We examined the detailed in situ expression pattern of thymosin beta 4 (Tβ4) in the developing mouse mandibular first molar. Tβ4 mRNA was expressed in the presumptive dental epithelium at embryonic day 10.5 (E10.5) and in the thickened dental epithelium at E12. An in situ signal was observed in the invaginated epithelial bud at E13, in the enamel organ at E14 and E14.5, and in the primary enamel knot (PEK) at E14.5. The signal was localized in the epithelial cells of the outer layer of the enamel organ at E15 and E15.5. No signal was found in the PEK at these stages. Tβ4 mRNA was expressed in the inner enamel epithelium, cervical loop and dental lamina at E16 and E17. The expression of Tβ4 mRNA was observed in the polarized inner epithelial cells at E18, newborn day 1 (N1) and N2. However, the signal intensity decreased markedly at N3. We herein report for the first time that Tβ4 is distinctly expressed in developing tooth germ, and it may also play functional roles in the initiation, growth and differentiation of tooth germ.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalHistochemistry and Cell Biology
Issue number3-4
Publication statusPublished - Sep 2005

All Science Journal Classification (ASJC) codes

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology


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