Possible role of cytomegalovirus infection in the pathogenesis of human vascular diseases

Y. Yonemitsu, K. Komori, K. Sueishi, K. Sugimachi

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

In order to evaluate the pathogenic role of human cytomegalovirus(CMV) infection in human vascular disease, we first examined the role of CMV immediate early gene (CMV-IE) expression in vascular smooth muscle cell (VSMC) proliferation. The in vitro IE gene transfer stimulated VSMC proliferation. The in vivo IE gene transfer showed neointimal thickening while the control arteries did not. In the wall of "so-called" inflammatory abdominal aortic aneurysm (IAAA), CMV infected cells were more frequently encountered than in that of AA and control cases. CMV infected cells were largely identified as macrophages or fibroblasts, and these cells frequently expressed CMV-IE gene. These findings thus suggest that the persistent expression of CMV-IE gene in the vessel wall may play a role in the vascular cellular responses, including progression of atherosclerosis or vasculitis, in vivo.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume56
Issue number1
Publication statusPublished - Jan 1998

Fingerprint

Cytomegalovirus Infections
Cytomegalovirus
Vascular Diseases
Vascular Smooth Muscle
Genes
Smooth Muscle Myocytes
Cell Proliferation
Immediate-Early Genes
Abdominal Aortic Aneurysm
Vasculitis
Blood Vessels
Atherosclerosis
Arteries
Fibroblasts
Macrophages
Gene Expression

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Possible role of cytomegalovirus infection in the pathogenesis of human vascular diseases. / Yonemitsu, Y.; Komori, K.; Sueishi, K.; Sugimachi, K.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 56, No. 1, 01.1998, p. 102-108.

Research output: Contribution to journalReview article

@article{e9d2e7e579874a0bbb4abd551d54dbf8,
title = "Possible role of cytomegalovirus infection in the pathogenesis of human vascular diseases",
abstract = "In order to evaluate the pathogenic role of human cytomegalovirus(CMV) infection in human vascular disease, we first examined the role of CMV immediate early gene (CMV-IE) expression in vascular smooth muscle cell (VSMC) proliferation. The in vitro IE gene transfer stimulated VSMC proliferation. The in vivo IE gene transfer showed neointimal thickening while the control arteries did not. In the wall of {"}so-called{"} inflammatory abdominal aortic aneurysm (IAAA), CMV infected cells were more frequently encountered than in that of AA and control cases. CMV infected cells were largely identified as macrophages or fibroblasts, and these cells frequently expressed CMV-IE gene. These findings thus suggest that the persistent expression of CMV-IE gene in the vessel wall may play a role in the vascular cellular responses, including progression of atherosclerosis or vasculitis, in vivo.",
author = "Y. Yonemitsu and K. Komori and K. Sueishi and K. Sugimachi",
year = "1998",
month = "1",
language = "English",
volume = "56",
pages = "102--108",
journal = "Astrophysical Journal",
issn = "0004-637X",
publisher = "IOP Publishing Ltd.",
number = "1",

}

TY - JOUR

T1 - Possible role of cytomegalovirus infection in the pathogenesis of human vascular diseases

AU - Yonemitsu, Y.

AU - Komori, K.

AU - Sueishi, K.

AU - Sugimachi, K.

PY - 1998/1

Y1 - 1998/1

N2 - In order to evaluate the pathogenic role of human cytomegalovirus(CMV) infection in human vascular disease, we first examined the role of CMV immediate early gene (CMV-IE) expression in vascular smooth muscle cell (VSMC) proliferation. The in vitro IE gene transfer stimulated VSMC proliferation. The in vivo IE gene transfer showed neointimal thickening while the control arteries did not. In the wall of "so-called" inflammatory abdominal aortic aneurysm (IAAA), CMV infected cells were more frequently encountered than in that of AA and control cases. CMV infected cells were largely identified as macrophages or fibroblasts, and these cells frequently expressed CMV-IE gene. These findings thus suggest that the persistent expression of CMV-IE gene in the vessel wall may play a role in the vascular cellular responses, including progression of atherosclerosis or vasculitis, in vivo.

AB - In order to evaluate the pathogenic role of human cytomegalovirus(CMV) infection in human vascular disease, we first examined the role of CMV immediate early gene (CMV-IE) expression in vascular smooth muscle cell (VSMC) proliferation. The in vitro IE gene transfer stimulated VSMC proliferation. The in vivo IE gene transfer showed neointimal thickening while the control arteries did not. In the wall of "so-called" inflammatory abdominal aortic aneurysm (IAAA), CMV infected cells were more frequently encountered than in that of AA and control cases. CMV infected cells were largely identified as macrophages or fibroblasts, and these cells frequently expressed CMV-IE gene. These findings thus suggest that the persistent expression of CMV-IE gene in the vessel wall may play a role in the vascular cellular responses, including progression of atherosclerosis or vasculitis, in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0031606947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031606947&partnerID=8YFLogxK

M3 - Review article

C2 - 9465673

AN - SCOPUS:0031606947

VL - 56

SP - 102

EP - 108

JO - Astrophysical Journal

JF - Astrophysical Journal

SN - 0004-637X

IS - 1

ER -