Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China

Yoichi Nakanishi, S. Chen, S. Inutsuka, Y. Ma, X. Jiang, N. Hara, N. Sera, H. Tokiwa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fuyuan Country, in Yunnan Province, China has an extremely high lung cancer mortality both in males and non-smoking females. Out of 5768 deaths, 588 patients died of malignant diseases. Lung cancer was the number one cause of death among malignant diseases both in males and females. The rate of lung cancer death to the whole of malignant diseases was 56.2% for males and 55.0% for females. Indoor soot and combustion emission derived from smoky coal produced in northern Fuyuan exhibited high mutagenic activities against Salmonella typhimurium TA98 strain in Ames test. Resected lung tissues derived from the patients with lung cancer in Fuyuan contained significantly higher concentrations of benzo(a)pyrene than those in Japan, both in males and females (i.e., 608.7 ± 477.1 pg/dry weight for samples of the patients in Fuyuan, 180.1 ± 104.5 for Japanese non-smokers, and 207.5 ± 98.8 for Japanese heavy smokers, respectively). These results suggest that mutagenic chemicals contained in coal as well as indoor environment may have a great influence on lung carcinogenesis in Fuyuan, Yunnan Province, China.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalNeoplasma
Volume44
Issue number1
Publication statusPublished - May 12 1997

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Coal
China
Carcinogenesis
Lung Neoplasms
Lung
Soot
Benzo(a)pyrene
Salmonella typhimurium
Cause of Death
Japan
fu-yuan
Weights and Measures
Mortality

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Nakanishi, Y., Chen, S., Inutsuka, S., Ma, Y., Jiang, X., Hara, N., ... Tokiwa, H. (1997). Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China. Neoplasma, 44(1), 69-72.

Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China. / Nakanishi, Yoichi; Chen, S.; Inutsuka, S.; Ma, Y.; Jiang, X.; Hara, N.; Sera, N.; Tokiwa, H.

In: Neoplasma, Vol. 44, No. 1, 12.05.1997, p. 69-72.

Research output: Contribution to journalArticle

Nakanishi, Y, Chen, S, Inutsuka, S, Ma, Y, Jiang, X, Hara, N, Sera, N & Tokiwa, H 1997, 'Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China', Neoplasma, vol. 44, no. 1, pp. 69-72.
Nakanishi Y, Chen S, Inutsuka S, Ma Y, Jiang X, Hara N et al. Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China. Neoplasma. 1997 May 12;44(1):69-72.
Nakanishi, Yoichi ; Chen, S. ; Inutsuka, S. ; Ma, Y. ; Jiang, X. ; Hara, N. ; Sera, N. ; Tokiwa, H. / Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China. In: Neoplasma. 1997 ; Vol. 44, No. 1. pp. 69-72.
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