Possible role of placental leptin in pregnancy: A review

Norimasa Sagawa, Shigeo Yura, Hiroaki Itoh, Kazuyo Kakui, Maki Takemura, Mercy A. Nuamah, Yoshihiro Ogawa, Hiroaki Masuzaki, Kazuwa Nakao, Shingo Fujii

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Leptin was initially identified as an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. Subsequent animal studies revealed various physiologic functions of leptin. Leptin plays an essential role in reproduction by regulating gonadotropin-releasing hormone secretion from the hypothalamus. It also modulates glucose metabolism by increasing insulin sensitivity and activates the sympathetic nervous system. In humans, leptin is also produced by placental trophoblasts and is secreted into both the maternal and fetal circulation. Leptin production in the placenta is increased in pregnancies complicated with several pathologic conditions. Leptin gene expression in the placenta is augmented in severe preeclampsia, and maternal plasma leptin levels in severe preeclampsia are significantly higher than those in normotensive pregnant women. Leptin production in the placenta is also increased in diabetic pregnancy with insulin treatment. Furthermore, leptin is proposed to play a functional role in implantation by virtue of its stimulatory effect on matrix metalloproteinase expression in cytotrophoblast. Dysregulation of leptin metabolism and/or function in the placenta may be implicated in the pathogenesis of various disorders during pregnancy, such as recurrent miscarriage, gestational diabetes, intrauterine growth retardation, and preeclampsia. In this review, possible roles of placental leptin are discussed.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalEndocrine
Volume19
Issue number1
DOIs
Publication statusPublished - Oct 1 2002
Externally publishedYes

Fingerprint

Leptin
Pregnancy
Placenta
Pre-Eclampsia
Trophoblasts
Hypothalamus
Mothers
Pregnancy in Diabetics
Habitual Abortion
Gestational Diabetes
Fetal Growth Retardation
Sympathetic Nervous System
Matrix Metalloproteinases
Adipocytes
Gonadotropin-Releasing Hormone
Reproduction
Insulin Resistance
Pregnant Women
Eating
Body Weight

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Sagawa, N., Yura, S., Itoh, H., Kakui, K., Takemura, M., Nuamah, M. A., ... Fujii, S. (2002). Possible role of placental leptin in pregnancy: A review. Endocrine, 19(1), 65-71. https://doi.org/10.1385/ENDO:19:1:65

Possible role of placental leptin in pregnancy : A review. / Sagawa, Norimasa; Yura, Shigeo; Itoh, Hiroaki; Kakui, Kazuyo; Takemura, Maki; Nuamah, Mercy A.; Ogawa, Yoshihiro; Masuzaki, Hiroaki; Nakao, Kazuwa; Fujii, Shingo.

In: Endocrine, Vol. 19, No. 1, 01.10.2002, p. 65-71.

Research output: Contribution to journalReview article

Sagawa, N, Yura, S, Itoh, H, Kakui, K, Takemura, M, Nuamah, MA, Ogawa, Y, Masuzaki, H, Nakao, K & Fujii, S 2002, 'Possible role of placental leptin in pregnancy: A review', Endocrine, vol. 19, no. 1, pp. 65-71. https://doi.org/10.1385/ENDO:19:1:65
Sagawa N, Yura S, Itoh H, Kakui K, Takemura M, Nuamah MA et al. Possible role of placental leptin in pregnancy: A review. Endocrine. 2002 Oct 1;19(1):65-71. https://doi.org/10.1385/ENDO:19:1:65
Sagawa, Norimasa ; Yura, Shigeo ; Itoh, Hiroaki ; Kakui, Kazuyo ; Takemura, Maki ; Nuamah, Mercy A. ; Ogawa, Yoshihiro ; Masuzaki, Hiroaki ; Nakao, Kazuwa ; Fujii, Shingo. / Possible role of placental leptin in pregnancy : A review. In: Endocrine. 2002 ; Vol. 19, No. 1. pp. 65-71.
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