TY - JOUR
T1 - Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa
AU - Ando, Tetsuya
AU - Komaki, Gen
AU - Naruo, Tetsuro
AU - Okabe, Kenjiro
AU - Takii, Masato
AU - Kawai, Keisuke
AU - Konjiki, Fujiko
AU - Takei, Michiko
AU - Oka, Takakazu
AU - Takeuchi, Kaori
AU - Masuda, Akinori
AU - Ozaki, Norio
AU - Suematsu, Hiroyuki
AU - Denda, Kenzo
AU - Kurokawa, Nobuo
AU - Itakura, Kotarou
AU - Yamaguchi, Chikara
AU - Kono, Masaki
AU - Suzuki, Tatsuyo
AU - Nakai, Yoshikatsu
AU - Nishizono-Maher, Aya
AU - Koide, Masanori
AU - Murakami, Ken
AU - Nagamine, Kiyohide
AU - Tomita, Yuichiro
AU - Ookuma, Kazuyoshi
AU - Tomita, Kazumi
AU - Tonai, Eita
AU - Ooshima, Akira
AU - Ishikawa, Toshio
AU - Ichimaru, Yuhei
PY - 2006/12/5
Y1 - 2006/12/5
N2 - Previous investigations have suggested that ghrelin, an endogenous orexigenic peptide, is involved in the pathology of eating disorders. We conducted a study to determine whether any preproghrelin gene polymorphisms are associated with eating disorders. Three hundred thirty-six eating disorder patients, including 131 anorexia nervosa (AN)-restricting types (AN-R), 97 AN-binge eating/purging types (AN-BP) and 108 bulimia nervosa (BN)-purging types (BN-P), and 300 healthy control subjects participated in the study. Genotyping was performed to determine the polymorphisms present, and with this information, linkage disequilibrium (LD) between the markers was analyzed and the distributions of the genotypes, the allele frequencies, and the haplotype frequencies were compared between the groups. The Leu72Met (408 C > A) (rs696217) polymorphism in exon 2 and the 3056 T > C (rs2075356) polymorphism in intron 2 were in LD (D′ = 0.902, r2 = 0.454). Both polymorphisms were significantly associated with BN-P (allele-wise: P = 0.0410, odds ratio (OR) = 1.48; P = 0.0035, OR = 1.63, for Leu72Met and 3056 T > C, respectively). In addition, we observed a significant increase in the frequency of the haplotype Met72-3056C in BN-P patients (P = 0.0059, OR = 1.71). Our findings suggest that the Leu72-Met (408 C > A) and the 3056 T > C polymorphisms of the preproghrelin gene are associated with susceptibility to BN-P.
AB - Previous investigations have suggested that ghrelin, an endogenous orexigenic peptide, is involved in the pathology of eating disorders. We conducted a study to determine whether any preproghrelin gene polymorphisms are associated with eating disorders. Three hundred thirty-six eating disorder patients, including 131 anorexia nervosa (AN)-restricting types (AN-R), 97 AN-binge eating/purging types (AN-BP) and 108 bulimia nervosa (BN)-purging types (BN-P), and 300 healthy control subjects participated in the study. Genotyping was performed to determine the polymorphisms present, and with this information, linkage disequilibrium (LD) between the markers was analyzed and the distributions of the genotypes, the allele frequencies, and the haplotype frequencies were compared between the groups. The Leu72Met (408 C > A) (rs696217) polymorphism in exon 2 and the 3056 T > C (rs2075356) polymorphism in intron 2 were in LD (D′ = 0.902, r2 = 0.454). Both polymorphisms were significantly associated with BN-P (allele-wise: P = 0.0410, odds ratio (OR) = 1.48; P = 0.0035, OR = 1.63, for Leu72Met and 3056 T > C, respectively). In addition, we observed a significant increase in the frequency of the haplotype Met72-3056C in BN-P patients (P = 0.0059, OR = 1.71). Our findings suggest that the Leu72-Met (408 C > A) and the 3056 T > C polymorphisms of the preproghrelin gene are associated with susceptibility to BN-P.
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U2 - 10.1002/ajmg.b.30387
DO - 10.1002/ajmg.b.30387
M3 - Article
C2 - 16921495
AN - SCOPUS:33845384878
VL - 141
SP - 929
EP - 934
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 8
ER -
