Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer

Tomoyoshi Takenaka, Eiko Inamasu, Tsukihisa Yoshida, Gouji Toyokawa, Kaname Nosaki, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Mitsuhiro Takenoyama, Yukito Ichinose

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Abstract

Purpose: The purpose of this study was to evaluate the outcomes of elderly patients 75 years of age or older with recurrent non-small cell lung cancer (NSCLC). Methods: A total of 1237 consecutive patients with NSCLC underwent pulmonary resection at our institution. Of these patients, 280 experienced postoperative recurrence. The rate of the post-recurrence survival and predictors were analyzed independently in a group of younger patients (<75 years) and a group of elderly patients (≥75 years). Results: There were 215 younger patients (<75 years) and 65 elderly (≥75 years) patients at the time of diagnosis of recurrence. The median post-recurrence survival time and the five-year survival rate of all cases were 25 months and 20.8 %, respectively. There were no significant survival differences between the younger and elderly groups (p = 0.20). A univariate analysis determined that gender, Eastern Cooperative Oncology Group performance status, smoking status, histological type and epithelial growth factor receptor (EGFR) mutation status were factors influencing the post-recurrence survival among the elderly patients. In addition, a multivariate analysis determined the EGFR mutation status to be an independent prognostic factor for the post-recurrence survival. Conclusions: Elderly patients 75 years of age or older in this study achieved satisfactory long-term outcomes.

Original languageEnglish
Pages (from-to)430-436
Number of pages7
JournalSurgery today
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Surgery

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    Takenaka, T., Inamasu, E., Yoshida, T., Toyokawa, G., Nosaki, K., Hirai, F., Yamaguchi, M., Seto, T., Takenoyama, M., & Ichinose, Y. (2016). Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer. Surgery today, 46(4), 430-436. https://doi.org/10.1007/s00595-015-1200-9