Abstract
Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.
| Original language | English |
|---|---|
| Title of host publication | Protein Modifications in Pathogenic Dysregulation of Signaling |
| Publisher | Springer Japan |
| Pages | 327-342 |
| Number of pages | 16 |
| ISBN (Electronic) | 9784431555612 |
| ISBN (Print) | 9784431555605 |
| DOIs | |
| Publication status | Published - Sep 2 2015 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Post-translational modification of Tcf/Lef : New insights into the regulation of Wnt/β-catenin signaling. / Ishitani, Tohru.
Protein Modifications in Pathogenic Dysregulation of Signaling. Springer Japan, 2015. p. 327-342.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Post-translational modification of Tcf/Lef
T2 - New insights into the regulation of Wnt/β-catenin signaling
AU - Ishitani, Tohru
PY - 2015/9/2
Y1 - 2015/9/2
N2 - Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.
AB - Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.
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UR - http://www.scopus.com/inward/citedby.url?scp=84956482014&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-55561-2_20
DO - 10.1007/978-4-431-55561-2_20
M3 - Chapter
SN - 9784431555605
SP - 327
EP - 342
BT - Protein Modifications in Pathogenic Dysregulation of Signaling
PB - Springer Japan
ER -