Post-translational modification of Tcf/Lef: New insights into the regulation of Wnt/β-catenin signaling

Tohru Ishitani

doi:10.1007/978-4-431-55561-2_20

Post-translational modification of Tcf/Lef: New insights into the regulation of Wnt/β-catenin signaling

Tohru Ishitani

Department of Immunobiology and Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.

Original language	English
Title of host publication	Protein Modifications in Pathogenic Dysregulation of Signaling
Publisher	Springer Japan
Pages	327-342
Number of pages	16
ISBN (Electronic)	9784431555612
ISBN (Print)	9784431555605
DOIs	https://doi.org/10.1007/978-4-431-55561-2_20
Publication status	Published - Sep 2 2015

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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10.1007/978-4-431-55561-2_20

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abstract = "Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation and fate during embryogenesis and adult homeostasis. Extensive investigation during the past three decades has made clear that the post-translational modification of β-catenin is a main switch that controls Wnt/β- - catenin signaling in all cells; however, given that Wnt/β-catenin signaling has a great variety of functions, the pathway must be controlled by multiple switches to enable strict spatiotemporal regulation. For the past 15 years, our group has studied the phosphorylation and ubiquitination of Tcf/Lef and discovered that these modifi- cations contribute to the fine-tuning of Wnt/β-catenin signaling in Caenorhabditis elegans and zebrafish. This chapter summarizes our understanding of Tcf/Lef modification and its significance in embryonic development and tissue homeostasis, and discusses the utility of non-mouse animal models in cell signaling studies.",

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