Posterior Reversible Encephalopathy Syndrome during Combined Modality Therapy for Head and Neck Squamous Cell Carcinoma

Takahiro Wakasaki, Seiji Gotoh, Eri Tomonobe, Takenao Mihara, Junichi Fukushima

Research output: Contribution to journalArticle

Abstract

Objectives: Posterior reversible encephalopathy syndrome (PRES) is a rare and acute disease with central nervous system symptoms. Without appropriate therapy, patients may exhibit a poor prognosis. PRES should be recognized as a possible problem during therapy for head and neck squamous cell carcinoma (HNSCC). Methods: A 56-year-old female developed PRES during combined modality therapy for HNSCC. On the fourth day after surgery and following chemoradiotherapy, PRES developed with a sudden visual disorder, followed by headache located at the back of the head and convulsions accompanied by impaired consciousness. We diagnosed PRES based on the clinical manifestations and magnetic resonance imaging data. Results: The patient recovered from PRES by appropriate treatment. Conclusion: This is the first case report of PRES developed during treatment for HNSCC. Masked by other cerebrovascular disorders, more cases of PRES could exist than usually expected; therefore, we should consider PRES as a differential diagnosis for central nervous system disorders developing during high-intensity therapy.

Original languageEnglish
Pages (from-to)844-849
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume125
Issue number10
DOIs
Publication statusPublished - Oct 1 2016
Externally publishedYes

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Posterior Leukoencephalopathy Syndrome
Combined Modality Therapy
Therapeutics
Carcinoma, squamous cell of head and neck
Cerebrovascular Disorders
Central Nervous System Diseases
Vision Disorders
Chemoradiotherapy
Acute Disease
Rare Diseases
Consciousness
Ambulatory Surgical Procedures
Headache
Seizures
Differential Diagnosis
Central Nervous System
Head
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Posterior Reversible Encephalopathy Syndrome during Combined Modality Therapy for Head and Neck Squamous Cell Carcinoma. / Wakasaki, Takahiro; Gotoh, Seiji; Tomonobe, Eri; Mihara, Takenao; Fukushima, Junichi.

In: Annals of Otology, Rhinology and Laryngology, Vol. 125, No. 10, 01.10.2016, p. 844-849.

Research output: Contribution to journalArticle

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