Postmortem changes of triazolam concentrations in body tissues

Keiko Kudo, T. Nagata, K. Kimura, T. Imamura, N. Urakawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Postmortem changes of triazolam concentrations in body tissues were examined using rats, in order to find the most suitable tissue samples for toxicological analysis. Triazolam was orally given to rats (5 mg/kg), and then the rats were sacrificed 1 hour after administration. Tissue samples were collected 0, 1 and 2 days after storage at 22-24°C, and the triazolam concentration in each sample was measured using gas chromatography with a nitrogen phosphorus detector. Triazolam concentrations were markedly increased in the spleen, the abdominal muscle, the liver and the kidney, and were slightly increased in the blood and the lung. On the other hand, no changes were observed in the thigh muscle or the brain, and the value in the thigh muscle was similar to those in the blood samples collected immediately after death. The results indicate that triazolam diffuses into the surrounding tissues through the stomach wall after death, so that the thigh muscle and the brain have to be analyzed as well as the blood for a correct diagnosis of triazolam ingestion.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalJapanese Journal of Legal Medicine
Volume46
Issue number5
Publication statusPublished - Jan 1 1992

Fingerprint

Postmortem Changes
Triazolam
Thigh
Muscles
Abdominal Muscles
Brain
Gas Chromatography
Toxicology
Phosphorus
Stomach
Nitrogen
Spleen
Eating
Kidney
Lung
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kudo, K., Nagata, T., Kimura, K., Imamura, T., & Urakawa, N. (1992). Postmortem changes of triazolam concentrations in body tissues. Japanese Journal of Legal Medicine, 46(5), 293-296.

Postmortem changes of triazolam concentrations in body tissues. / Kudo, Keiko; Nagata, T.; Kimura, K.; Imamura, T.; Urakawa, N.

In: Japanese Journal of Legal Medicine, Vol. 46, No. 5, 01.01.1992, p. 293-296.

Research output: Contribution to journalArticle

Kudo, K, Nagata, T, Kimura, K, Imamura, T & Urakawa, N 1992, 'Postmortem changes of triazolam concentrations in body tissues', Japanese Journal of Legal Medicine, vol. 46, no. 5, pp. 293-296.
Kudo K, Nagata T, Kimura K, Imamura T, Urakawa N. Postmortem changes of triazolam concentrations in body tissues. Japanese Journal of Legal Medicine. 1992 Jan 1;46(5):293-296.
Kudo, Keiko ; Nagata, T. ; Kimura, K. ; Imamura, T. ; Urakawa, N. / Postmortem changes of triazolam concentrations in body tissues. In: Japanese Journal of Legal Medicine. 1992 ; Vol. 46, No. 5. pp. 293-296.
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