Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Qingjiang Hu, Yasuo Tsuda, Koichi Kimura, Ryota Nakanishi, Nobuhide Kubo, Koji Ando, Eiji Oki, Tetsuo Ikeda, Yoshihiko Maehara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalAmerican Journal of Surgery
Volume217
Issue number4
DOIs
Publication statusPublished - Apr 2019

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Sarcopenia
Esophagogastric Junction
Stomach Neoplasms
Adenocarcinoma
Multivariate Analysis
Survival Rate
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

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Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer. / Kudou, Kensuke; Saeki, Hiroshi; Nakashima, Yuichiro; Sasaki, Shun; Jogo, Tomoko; Hirose, Kosuke; Hu, Qingjiang; Tsuda, Yasuo; Kimura, Koichi; Nakanishi, Ryota; Kubo, Nobuhide; Ando, Koji; Oki, Eiji; Ikeda, Tetsuo; Maehara, Yoshihiko.

In: American Journal of Surgery, Vol. 217, No. 4, 04.2019, p. 757-763.

Research output: Contribution to journalArticle

Kudou, Kensuke ; Saeki, Hiroshi ; Nakashima, Yuichiro ; Sasaki, Shun ; Jogo, Tomoko ; Hirose, Kosuke ; Hu, Qingjiang ; Tsuda, Yasuo ; Kimura, Koichi ; Nakanishi, Ryota ; Kubo, Nobuhide ; Ando, Koji ; Oki, Eiji ; Ikeda, Tetsuo ; Maehara, Yoshihiko. / Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer. In: American Journal of Surgery. 2019 ; Vol. 217, No. 4. pp. 757-763.
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abstract = "Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0{\%} vs. 92.6{\%}, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.",
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AU - Kudou, Kensuke

AU - Saeki, Hiroshi

AU - Nakashima, Yuichiro

AU - Sasaki, Shun

AU - Jogo, Tomoko

AU - Hirose, Kosuke

AU - Hu, Qingjiang

AU - Tsuda, Yasuo

AU - Kimura, Koichi

AU - Nakanishi, Ryota

AU - Kubo, Nobuhide

AU - Ando, Koji

AU - Oki, Eiji

AU - Ikeda, Tetsuo

AU - Maehara, Yoshihiko

PY - 2019/4

Y1 - 2019/4

N2 - Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.

AB - Background: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). Methods: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. Results: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). Conclusions: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.

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