Postoperative pancreatic exocrine function influences body weight maintenance after pylorus-preserving pancreatoduodenectomy

Takao Ohtsuka, Koji Yamaguchi, Kazuo Chijiiwa, Masao Tanaka

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Most patients who undergo pylorus-preserving pancreatoduodenectomy (PPPD) are able to gain their weight postoperatively. However, sometimes patients experience a lack of weight gain even at long term after PPPD. The aim of this study was to examine factors influencing a body weight change after PPPD. Methods: In 34 Japanese patients with PPPD, 28 clinical parameters were assessed as possible factors affecting body weight maintenance at long term (1 year) after the operation by univariate and multivariate analyses. Results: Univariate analysis showed that long operation time (P = 0.02), extended retroperitoneal lymph node dissection (P = 0.0005), intraoperative radiotherapy (P = 0.02), adjuvant postoperative chemotherapy (P = 0.02), histopathological diagnosis of pancreatic cancer (P = 0.02), postoperative ulceration (P = 0.007), and insufficient postoperative pancreatic exocrine function (P = 0.002) were significantly related with the lack of weight gain at long term after PPPD. Multivariate analysis regarding the seven profound factors revealed that the insufficient postoperative pancreatic exocrine function significantly affected the lack of weight gain after PPPD. The use of ordinary amount of pancreatic exocrine enzymes did not influence the weight gain after PPPD (P = 0.23). Conclusions: In patients refractory to an ordinary amount of medicine, a large dosage of enzymes may be necessary to gain weight after PPPD.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalAmerican Journal of Surgery
Volume182
Issue number5
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint Dive into the research topics of 'Postoperative pancreatic exocrine function influences body weight maintenance after pylorus-preserving pancreatoduodenectomy'. Together they form a unique fingerprint.

Cite this