Postoperative recurrence of rectal cancer

Shigeu Yamada, Satoshi Endo, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, Tetsuro Isozaki

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94% at 3 years and 89% at 5 years. Local control rate and survival rate at 5 years were 97% at 73.6 GyE and 51% at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20-40%. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.

Original languageEnglish
Title of host publicationCarbon-Ion Radiotherapy
Subtitle of host publicationPrinciples, Practices, and Treatment Planning
PublisherSpringer Japan
Pages203-209
Number of pages7
ISBN (Electronic)9784431544579
ISBN (Print)9784431544562
DOIs
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Yamada, S., Endo, S., Terashima, K., Shinoto, M., Yasuda, S., Shiomi, M., & Isozaki, T. (2014). Postoperative recurrence of rectal cancer. In Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning (pp. 203-209). Springer Japan. https://doi.org/10.1007/978-4-431-54457-9_24