Postoperative recurrence of rectal cancer

Shigeu Yamada, Satoshi Endo, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, Tetsuro Isozaki

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94% at 3 years and 89% at 5 years. Local control rate and survival rate at 5 years were 97% at 73.6 GyE and 51% at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20-40%. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.

Original languageEnglish
Title of host publicationCarbon-Ion Radiotherapy
Subtitle of host publicationPrinciples, Practices, and Treatment Planning
PublisherSpringer Japan
Pages203-209
Number of pages7
ISBN (Electronic)9784431544579
ISBN (Print)9784431544562
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Heavy Ion Radiotherapy
Rectal Neoplasms
Recurrence
Survival Rate
Survival
Carbon
Ions
Radiation
Morbidity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yamada, S., Endo, S., Terashima, K., Shinoto, M., Yasuda, S., Shiomi, M., & Isozaki, T. (2014). Postoperative recurrence of rectal cancer. In Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning (pp. 203-209). Springer Japan. https://doi.org/10.1007/978-4-431-54457-9_24

Postoperative recurrence of rectal cancer. / Yamada, Shigeu; Endo, Satoshi; Terashima, Kohtaro; Shinoto, Makoto; Yasuda, Shigeo; Shiomi, Miho; Isozaki, Tetsuro.

Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning. Springer Japan, 2014. p. 203-209.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yamada, S, Endo, S, Terashima, K, Shinoto, M, Yasuda, S, Shiomi, M & Isozaki, T 2014, Postoperative recurrence of rectal cancer. in Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning. Springer Japan, pp. 203-209. https://doi.org/10.1007/978-4-431-54457-9_24
Yamada S, Endo S, Terashima K, Shinoto M, Yasuda S, Shiomi M et al. Postoperative recurrence of rectal cancer. In Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning. Springer Japan. 2014. p. 203-209 https://doi.org/10.1007/978-4-431-54457-9_24
Yamada, Shigeu ; Endo, Satoshi ; Terashima, Kohtaro ; Shinoto, Makoto ; Yasuda, Shigeo ; Shiomi, Miho ; Isozaki, Tetsuro. / Postoperative recurrence of rectal cancer. Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning. Springer Japan, 2014. pp. 203-209
@inbook{3d97bb72966f4e55a0e8db7d1721dfb0,
title = "Postoperative recurrence of rectal cancer",
abstract = "To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94{\%} at 3 years and 89{\%} at 5 years. Local control rate and survival rate at 5 years were 97{\%} at 73.6 GyE and 51{\%} at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20-40{\%}. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.",
author = "Shigeu Yamada and Satoshi Endo and Kohtaro Terashima and Makoto Shinoto and Shigeo Yasuda and Miho Shiomi and Tetsuro Isozaki",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-4-431-54457-9_24",
language = "English",
isbn = "9784431544562",
pages = "203--209",
booktitle = "Carbon-Ion Radiotherapy",
publisher = "Springer Japan",
address = "Japan",

}

TY - CHAP

T1 - Postoperative recurrence of rectal cancer

AU - Yamada, Shigeu

AU - Endo, Satoshi

AU - Terashima, Kohtaro

AU - Shinoto, Makoto

AU - Yasuda, Shigeo

AU - Shiomi, Miho

AU - Isozaki, Tetsuro

PY - 2014/1/1

Y1 - 2014/1/1

N2 - To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94% at 3 years and 89% at 5 years. Local control rate and survival rate at 5 years were 97% at 73.6 GyE and 51% at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20-40%. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.

AB - To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Between April 2001 and August 2012, 198 lesions at 189 patients were treated with C-ion RT. The dose was determined as 67.2 GyE and escalated to 70.4 GyE and 73.6 GyE. The local control rates in 197 lesions are 94% at 3 years and 89% at 5 years. Local control rate and survival rate at 5 years were 97% at 73.6 GyE and 51% at 73.6 GyE. In the literature, the reported 5-year survival rates for locally recurrent rectal cancer treated with resection were 20-40%. Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. In this chapter, the treatment methods and the up-to-date outcomes of carbon ion radiotherapy (C-ion RT) for the recurrent rectal cancer at the NIRS are introduced.

UR - http://www.scopus.com/inward/record.url?scp=84919785793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919785793&partnerID=8YFLogxK

U2 - 10.1007/978-4-431-54457-9_24

DO - 10.1007/978-4-431-54457-9_24

M3 - Chapter

AN - SCOPUS:84919785793

SN - 9784431544562

SP - 203

EP - 209

BT - Carbon-Ion Radiotherapy

PB - Springer Japan

ER -