Postprandial increase in plasma concentrations of remnant-like particles: An independent risk factor for restenosis after percutaneous coronary intervention

Keiji Oi, Hiroaki Shimokawa, Yoji Hirakawa, Hideki Tashiro, Ryuichi Nakaike, Toshiyuki Kozai, Keizaburo Ohzono, Kunihiko Yamamoto, Samon Koyanagi, Shuichi Okamatsu, Tsukasa Tajimi, Yutaka Kikuchi, Akira Takeshita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Postprandial increase in remnant lipoprotein concentrations has been suggested as an important atherogenic factor. However, the influence of these remnants on the development of restenosis after percutaneous coronary intervention (PCI) remains to be examined. The present study was designed to address this point. In 60 consecutive patients with successful PCI, the influences of possible risk factors on the development of restenosis, including remnant-like particles (RLP) cholesterol (RLP-C) and triglyceride (RLP-TG), were examined. While mean concentrations of RLP-C and RLP-TG were normal in fasting state, postprandial change in RLP-C concentrations was a significant and independent risk factor for restenosis after PCI. The calculated cut-off index (COI) for the change was +64%. When the patients were divided into 2 groups according to this COI, minimal lumen diameter (MLD) and reference coronary diameter were comparable before and immediately after PCI between the high- (COI ≥ 64%) and the low- (COI < 64%) responders. However, follow-up coronary angiography 3 to 6 months after PCI demonstrated that MLD, late loss, and loss index were all worse in the high responders compared with the low responders. These results indicate that postprandial increase in RLP-C concentrations is an independent risk factor for restenosis after successful PCI, even in patients with normal fasting RLP-C levels.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume44
Issue number1
DOIs
Publication statusPublished - Jul 1 2004

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Percutaneous Coronary Intervention
Fasting
Coronary Angiography
Lipoproteins
Triglycerides

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Postprandial increase in plasma concentrations of remnant-like particles : An independent risk factor for restenosis after percutaneous coronary intervention. / Oi, Keiji; Shimokawa, Hiroaki; Hirakawa, Yoji; Tashiro, Hideki; Nakaike, Ryuichi; Kozai, Toshiyuki; Ohzono, Keizaburo; Yamamoto, Kunihiko; Koyanagi, Samon; Okamatsu, Shuichi; Tajimi, Tsukasa; Kikuchi, Yutaka; Takeshita, Akira.

In: Journal of Cardiovascular Pharmacology, Vol. 44, No. 1, 01.07.2004, p. 66-73.

Research output: Contribution to journalArticle

Oi, K, Shimokawa, H, Hirakawa, Y, Tashiro, H, Nakaike, R, Kozai, T, Ohzono, K, Yamamoto, K, Koyanagi, S, Okamatsu, S, Tajimi, T, Kikuchi, Y & Takeshita, A 2004, 'Postprandial increase in plasma concentrations of remnant-like particles: An independent risk factor for restenosis after percutaneous coronary intervention', Journal of Cardiovascular Pharmacology, vol. 44, no. 1, pp. 66-73. https://doi.org/10.1097/00005344-200407000-00009
Oi, Keiji ; Shimokawa, Hiroaki ; Hirakawa, Yoji ; Tashiro, Hideki ; Nakaike, Ryuichi ; Kozai, Toshiyuki ; Ohzono, Keizaburo ; Yamamoto, Kunihiko ; Koyanagi, Samon ; Okamatsu, Shuichi ; Tajimi, Tsukasa ; Kikuchi, Yutaka ; Takeshita, Akira. / Postprandial increase in plasma concentrations of remnant-like particles : An independent risk factor for restenosis after percutaneous coronary intervention. In: Journal of Cardiovascular Pharmacology. 2004 ; Vol. 44, No. 1. pp. 66-73.
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