Potential molecular targets for anti-obesity drugs - After the discovery of leptin

S. Hidaka, Y. Ogawa, K. Nakao

Research output: Contribution to journalReview article

Abstract

The discovery of the adipose-derived hormone leptin has generated interest in the interaction between peripheral signals and brain targets involved in the regulation of feedings and energy balance. Potential anti-obesity drugs can be based on any intervention between the neuropeptide and its receptor that would alter the biological responses mediated by the neuronal network, in particular, food intake, metabolism and energy expenditure. Modulation of neurons in the arcuate nucleus by leptin results in reduced expression of neuropeptide Y and agouti-related protein, and increased expression of pro-opiomelanocortin (the precursor of a-melanocyte-stimulating hormone) and cocaine- and amphetamine- regulated transcript. Whether leptin finds its way into general usage as an anti-obesity drug, the use of modern methods to identify and target the components of leptin signaling pathway will form the basis for new pharmacological approaches to the treatment of obesity.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalFolia Pharmacologica Japonica
Volume118
Issue number5
DOIs
Publication statusPublished - Dec 17 2001
Externally publishedYes

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Anti-Obesity Agents
Drug Discovery
Leptin
Agouti-Related Protein
Neuropeptide Receptors
Melanocyte-Stimulating Hormones
Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Neuropeptide Y
Amphetamine
Cocaine
Energy Metabolism
Obesity
Eating
Hormones
Pharmacology
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Potential molecular targets for anti-obesity drugs - After the discovery of leptin. / Hidaka, S.; Ogawa, Y.; Nakao, K.

In: Folia Pharmacologica Japonica, Vol. 118, No. 5, 17.12.2001, p. 309-314.

Research output: Contribution to journalReview article

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