TY - JOUR
T1 - Potential role of PM2.5 in melanogenesis
AU - Peng, Fen
AU - Tsuji, Gaku
AU - Zhang, Jian zhong
AU - Chen, Zhou
AU - Furue, Masutaka
N1 - Publisher Copyright:
© 2019 The Authors
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - Ambient particulate matter 2.5 (PM2.5) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect of PM2.5 on human skin and its biological significance in skin homeostasis remain incompletely understood. Previous studies demonstrated that PM2.5 can activate aryl hydrocarbon receptor (AhR), generate reactive oxygen species, and induce skin inflammation. These processes may be involved in melanocyte homeostasis and melanogenesis. We hypothesize that AhR signaling may be responsible for PM2.5-related hyperpigmentation.
AB - Ambient particulate matter 2.5 (PM2.5) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect of PM2.5 on human skin and its biological significance in skin homeostasis remain incompletely understood. Previous studies demonstrated that PM2.5 can activate aryl hydrocarbon receptor (AhR), generate reactive oxygen species, and induce skin inflammation. These processes may be involved in melanocyte homeostasis and melanogenesis. We hypothesize that AhR signaling may be responsible for PM2.5-related hyperpigmentation.
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U2 - 10.1016/j.envint.2019.105063
DO - 10.1016/j.envint.2019.105063
M3 - Review article
C2 - 31394397
AN - SCOPUS:85072546346
VL - 132
JO - Environmental International
JF - Environmental International
SN - 0160-4120
M1 - 105063
ER -