Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor

Yuji Yonezawa, Toshihide Kuroki, Nobutada Tashiro, Hisao Hondo, Hideyuki Uchimura

Research output: Contribution to journalArticle

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Abstract

Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalEuropean Journal of Pharmacology
Volume285
Issue number3
DOIs
Publication statusPublished - Oct 24 1995

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Phencyclidine
Dopamine D2 Receptors
Dopamine
Autoreceptors
Dopamine D1 Receptors
Dopamine Antagonists
Microdialysis
Perfusion
nemonapride

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor. / Yonezawa, Yuji; Kuroki, Toshihide; Tashiro, Nobutada; Hondo, Hisao; Uchimura, Hideyuki.

In: European Journal of Pharmacology, Vol. 285, No. 3, 24.10.1995, p. 305-308.

Research output: Contribution to journalArticle

Yonezawa, Yuji ; Kuroki, Toshihide ; Tashiro, Nobutada ; Hondo, Hisao ; Uchimura, Hideyuki. / Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor. In: European Journal of Pharmacology. 1995 ; Vol. 285, No. 3. pp. 305-308.
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