Potentiation of phencyclidine-induced dopamine release in the rat striatum by the blockade of dopamine D2 receptor

Yuji Yonezawa, Toshihide Kuroki, Nobutada Tashiro, Hisao Hondo, Hideyuki Uchimura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalEuropean Journal of Pharmacology
Volume285
Issue number3
DOIs
Publication statusPublished - Oct 24 1995

All Science Journal Classification (ASJC) codes

  • Pharmacology

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