TY - JOUR
T1 - Potentiation of physical dependence on diazepam by ondansetron in rats
AU - Mizoguchi, Hirokazu
AU - Shirayama, Naomi
AU - Tsuda, Makoto
AU - Yoshiike, Michiharu
AU - Suzuki, Tsutomu
AU - Misawa, Miwa
N1 - Funding Information:
This work was supported by a scientific research grant to T. Suzuki from the Ministry of Public Welfare, Japan.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - The effects of ondansetron, a 5-HT3 antagonist, on the development of physical dependence on diazepam were examined in rats using a drug-admixed food method. Rats were treated with diazepam or diazepam in combination with ondansetron for 26 days. After an abrupt withdrawal from diazepam, the incidence of withdrawal signs, such as jerks, tremors and convulsions, and withdrawal scores, were potentiated by co-administration of ondasetron. On the other hand, rats which had been treated with ondansetron alone for 33 days did not show any withdrawal signs after abrupt withdrawal from ondansetron. These findings suggest that ondansetron does not possess physical dependence liability, but does potentiate the development of physical dependence on diazepam. Regulation of serotonergic neurons through 5-HT3 receptors may affect the development of physical dependence on diazepam.
AB - The effects of ondansetron, a 5-HT3 antagonist, on the development of physical dependence on diazepam were examined in rats using a drug-admixed food method. Rats were treated with diazepam or diazepam in combination with ondansetron for 26 days. After an abrupt withdrawal from diazepam, the incidence of withdrawal signs, such as jerks, tremors and convulsions, and withdrawal scores, were potentiated by co-administration of ondasetron. On the other hand, rats which had been treated with ondansetron alone for 33 days did not show any withdrawal signs after abrupt withdrawal from ondansetron. These findings suggest that ondansetron does not possess physical dependence liability, but does potentiate the development of physical dependence on diazepam. Regulation of serotonergic neurons through 5-HT3 receptors may affect the development of physical dependence on diazepam.
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U2 - 10.1016/0024-3205(94)00871-X
DO - 10.1016/0024-3205(94)00871-X
M3 - Article
C2 - 8114607
AN - SCOPUS:19244377416
SN - 0024-3205
VL - 54
SP - PL131-PL136
JO - Life Sciences
JF - Life Sciences
IS - 9
ER -