Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Kohei Torikai, Takayoshi Saruwatari, Tatsuya Kitano, Takuya Sano, Atsuko Nakane, Hiroshi Noguchi, Kenji Watanabe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalLetters in Organic Chemistry
Volume8
Issue number10
DOIs
Publication statusPublished - Dec 1 2011

Fingerprint

trabectedin
Biological Products
Purification
Crystallization
High Pressure Liquid Chromatography
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

Cite this

Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743. / Torikai, Kohei; Saruwatari, Takayoshi; Kitano, Tatsuya; Sano, Takuya; Nakane, Atsuko; Noguchi, Hiroshi; Watanabe, Kenji.

In: Letters in Organic Chemistry, Vol. 8, No. 10, 01.12.2011, p. 686-689.

Research output: Contribution to journalArticle

Torikai, Kohei ; Saruwatari, Takayoshi ; Kitano, Tatsuya ; Sano, Takuya ; Nakane, Atsuko ; Noguchi, Hiroshi ; Watanabe, Kenji. / Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743. In: Letters in Organic Chemistry. 2011 ; Vol. 8, No. 10. pp. 686-689.
@article{543a17df6c54481d91706ad82fd3107e,
title = "Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743",
abstract = "A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.",
author = "Kohei Torikai and Takayoshi Saruwatari and Tatsuya Kitano and Takuya Sano and Atsuko Nakane and Hiroshi Noguchi and Kenji Watanabe",
year = "2011",
month = "12",
day = "1",
doi = "10.2174/157017811799304160",
language = "English",
volume = "8",
pages = "686--689",
journal = "Letters in Organic Chemistry",
issn = "1570-1786",
publisher = "Bentham Science Publishers B.V.",
number = "10",

}

TY - JOUR

T1 - Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

AU - Torikai, Kohei

AU - Saruwatari, Takayoshi

AU - Kitano, Tatsuya

AU - Sano, Takuya

AU - Nakane, Atsuko

AU - Noguchi, Hiroshi

AU - Watanabe, Kenji

PY - 2011/12/1

Y1 - 2011/12/1

N2 - A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.

AB - A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.

UR - http://www.scopus.com/inward/record.url?scp=84858981826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858981826&partnerID=8YFLogxK

U2 - 10.2174/157017811799304160

DO - 10.2174/157017811799304160

M3 - Article

VL - 8

SP - 686

EP - 689

JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

SN - 1570-1786

IS - 10

ER -