TY - JOUR
T1 - Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743
AU - Torikai, Kohei
AU - Saruwatari, Takayoshi
AU - Kitano, Tatsuya
AU - Sano, Takuya
AU - Nakane, Atsuko
AU - Noguchi, Hiroshi
AU - Watanabe, Kenji
PY - 2011/12
Y1 - 2011/12
N2 - A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.
AB - A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.
UR - http://www.scopus.com/inward/record.url?scp=84858981826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858981826&partnerID=8YFLogxK
U2 - 10.2174/157017811799304160
DO - 10.2174/157017811799304160
M3 - Article
AN - SCOPUS:84858981826
SN - 1570-1786
VL - 8
SP - 686
EP - 689
JO - Letters in Organic Chemistry
JF - Letters in Organic Chemistry
IS - 10
ER -