Pre- and post-operative adjuvant chemotherapy in colorectal cancer.

Hiroharu Isomoto, Masao Tomita, Keizo Sugimachi, Michio Ogawa, Kazutaka Yamada, Tohru Nakagoe, Masaki Mori, Sadamu Takano, Teruo Kakegawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A multi-center randomized controlled study was conducted in order to investigate the usefulness of pre- and post-operative adjuvant chemotherapy in colorectal cancer. The patients were stratified into those with colon cancer and those with rectal cancer and divided into 2 groups, Group A and Group B. The patients in Group A received tegafur suppositories (750 mg/day) from 1 to 2 weeks prior to surgery, to 2 weeks following surgery and then oral administration of tegafur and uracil (UFT) (260 mg/m(2)) for 1 year. The patients in Group B, on the other hand, received only UFT (260 mg/m(2)) for 1 year beginning week 2 after surgery. Although there was no significant difference between Groups A and B in the 5-year survival rate, the 5-year disease-free survival rate was significantly higher in Group A, especially for rectal cancer (p<0.05). In addition, remote metastases tended to be suppressed for both colon and rectal cancer in Group A (p=0.08 and p=0.072). There was no serious adverse reaction to tegafur. Pre- and post-operative adjuvant chemotherapy with tegafur had fewer adverse reactions and was convenient to administer. Thus, it was considered useful for suppression of postoperative distant metastasis in colorectal cancer.

Original languageEnglish
Pages (from-to)1103-1108
Number of pages6
JournalInternational journal of oncology
Issue number4
Publication statusPublished - Oct 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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