Pre-Target axon sorting establishes the neural map topography

Takeshi Imai, Takahiro Yamazaki, Reiko Kobayakawa, Ko Kobayakawa, Takaya Abe, Misao Suzuki, Hitoshi Sakano

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139 Citations (Scopus)

Abstract

Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.

Original languageEnglish
Pages (from-to)585-590
Number of pages6
JournalScience
Volume325
Issue number5940
DOIs
Publication statusPublished - Jul 31 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • General

Cite this

Imai, T., Yamazaki, T., Kobayakawa, R., Kobayakawa, K., Abe, T., Suzuki, M., & Sakano, H. (2009). Pre-Target axon sorting establishes the neural map topography. Science, 325(5940), 585-590. https://doi.org/10.1126/science.1173596