Preattentive dysfunction in patients with bipolar disorder as revealed by the pitch-mismatch negativity: A magnetoencephalography (MEG) study

Satomi Shimano, Toshiaki Onitsuka, Naoya Oribe, Toshihiko Maekawa, Rikako Tsuchimoto, Shogo Hirano, Takefumi Ueno, Yoji Hirano, Tomofumi Miura, Shigenobu Kanba

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: Mismatch negativity (MMN) and its magnetic counterpart (MMNm) are thought to reflect an automatic process that detects a difference between an incoming stimulus and the sensory memory trace of preceding stimuli. In patients with schizophrenia, an attenuation of the MMN/MMNm amplitude has been repeatedly reported. Heschl's gyrus (HG) is one of the major generators of MMN and the functional alteration of HG has been reported in patients with bipolar disorder. The present study investigated the pitch-MMNm in patients with bipolar disorder using whole-head 306-ch magnetoencephalography (MEG). Methods: Twenty-two patients and 22 healthy controls participated in this study. Subjects were presented with two types of auditory stimulus sequences. One consisted of 1,000 Hz standards (probability = 90%) and 1,200 Hz deviants (probability = 10%), and the other consisted of 1,000 Hz standards (90%) and 1,200 Hz deviants (10%). These two tasks were each performed twice. Event-related brain responses to standard tones were subtracted from responses to deviant tones. Results: Patients with bipolar disorder showed a significant bilateral reduction in magnetic global field power (mGFP) amplitudes (p = 0.02) and dipole moments of the MMNm (p = 0.04) compared with healthy controls. Patients with admission experience showed significantly reduced mGFP amplitudes of MMNm compared with patients without admission experience (p = 0.004). Additionally, patients with more severe manic symptoms had smaller mGFP amplitudes of MMNm (ρ = -0.50, p = 0.05). Conclusions: The results of this study suggest that patients with bipolar disorder may exhibit preattentive auditory dysfunction indexed by reduced pitch-MMNm responses. Pitch-MMNm could be a potential trait marker reflecting the global severity of bipolar disorder.

Original languageEnglish
Pages (from-to)592-599
Number of pages8
JournalBipolar Disorders
Volume16
Issue number6
DOIs
Publication statusPublished - Jan 1 2014

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Magnetoencephalography
Bipolar Disorder
Magnetic Fields
Auditory Cortex
Patient Admission
Schizophrenia
Head
Brain

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Preattentive dysfunction in patients with bipolar disorder as revealed by the pitch-mismatch negativity : A magnetoencephalography (MEG) study. / Shimano, Satomi; Onitsuka, Toshiaki; Oribe, Naoya; Maekawa, Toshihiko; Tsuchimoto, Rikako; Hirano, Shogo; Ueno, Takefumi; Hirano, Yoji; Miura, Tomofumi; Kanba, Shigenobu.

In: Bipolar Disorders, Vol. 16, No. 6, 01.01.2014, p. 592-599.

Research output: Contribution to journalArticle

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abstract = "Objectives: Mismatch negativity (MMN) and its magnetic counterpart (MMNm) are thought to reflect an automatic process that detects a difference between an incoming stimulus and the sensory memory trace of preceding stimuli. In patients with schizophrenia, an attenuation of the MMN/MMNm amplitude has been repeatedly reported. Heschl's gyrus (HG) is one of the major generators of MMN and the functional alteration of HG has been reported in patients with bipolar disorder. The present study investigated the pitch-MMNm in patients with bipolar disorder using whole-head 306-ch magnetoencephalography (MEG). Methods: Twenty-two patients and 22 healthy controls participated in this study. Subjects were presented with two types of auditory stimulus sequences. One consisted of 1,000 Hz standards (probability = 90{\%}) and 1,200 Hz deviants (probability = 10{\%}), and the other consisted of 1,000 Hz standards (90{\%}) and 1,200 Hz deviants (10{\%}). These two tasks were each performed twice. Event-related brain responses to standard tones were subtracted from responses to deviant tones. Results: Patients with bipolar disorder showed a significant bilateral reduction in magnetic global field power (mGFP) amplitudes (p = 0.02) and dipole moments of the MMNm (p = 0.04) compared with healthy controls. Patients with admission experience showed significantly reduced mGFP amplitudes of MMNm compared with patients without admission experience (p = 0.004). Additionally, patients with more severe manic symptoms had smaller mGFP amplitudes of MMNm (ρ = -0.50, p = 0.05). Conclusions: The results of this study suggest that patients with bipolar disorder may exhibit preattentive auditory dysfunction indexed by reduced pitch-MMNm responses. Pitch-MMNm could be a potential trait marker reflecting the global severity of bipolar disorder.",
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AU - Shimano, Satomi

AU - Onitsuka, Toshiaki

AU - Oribe, Naoya

AU - Maekawa, Toshihiko

AU - Tsuchimoto, Rikako

AU - Hirano, Shogo

AU - Ueno, Takefumi

AU - Hirano, Yoji

AU - Miura, Tomofumi

AU - Kanba, Shigenobu

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