Predicting pelvic lymph node metastasis in endometrial carcinoma

Toshiharu Kamura, Hideaki Yahata, Toshiyuki Shigematsu, Shinji Ogawa, Satoshi Amada, Tsunehisa Kaku, Hitoo Nakano

Research output: Contribution to journalArticle

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Abstract

Background. To determine the possibility of individualizing the pelvic lymph node dissection in patients with endometrial cancer, the relationship between pelvic lymph node (PLN) metastasis and various prognostic factors was retrospectively investigated. Methods. From 1979 to 1994, 175 patients with endometrial carcinoma were treated with either total or radical hysterectomy combined with a PLN dissection as initial therapy. The prognostic factors examined included clinical stage, patient age, histological grade, the microscopic degree of myometrial invasion (DMI), cervical invasion, adnexal metastasis, and macroscopic tumor diameter (TD). Results. Of the 175 patients undergoing PLN dissection, 24 (14%) had PLN metastasis. An endometrial cancer with PLN metastasis had a significantly longer diameter than those without PLN metastasis. The frequency of PLN metastasis increased along with increases in tumor diameter. A logistic regression analysis revealed DMI and TD to be independently correlated with PLN metastasis. The formula based on the coefficients of TD and DMI obtained from the analysis also showed a good correlation, which allowed us to estimate the probability of patients having PLN metastasis. Conclusions. DMI and TD could accurately estimate the status of PLN in endometrial carcinoma patients.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalGynecologic Oncology
Volume72
Issue number3
DOIs
Publication statusPublished - Mar 1999

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Endometrial Neoplasms
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Neoplasms
Hysterectomy
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Kamura, T., Yahata, H., Shigematsu, T., Ogawa, S., Amada, S., Kaku, T., & Nakano, H. (1999). Predicting pelvic lymph node metastasis in endometrial carcinoma. Gynecologic Oncology, 72(3), 387-391. https://doi.org/10.1006/gyno.1998.5288

Predicting pelvic lymph node metastasis in endometrial carcinoma. / Kamura, Toshiharu; Yahata, Hideaki; Shigematsu, Toshiyuki; Ogawa, Shinji; Amada, Satoshi; Kaku, Tsunehisa; Nakano, Hitoo.

In: Gynecologic Oncology, Vol. 72, No. 3, 03.1999, p. 387-391.

Research output: Contribution to journalArticle

Kamura, T, Yahata, H, Shigematsu, T, Ogawa, S, Amada, S, Kaku, T & Nakano, H 1999, 'Predicting pelvic lymph node metastasis in endometrial carcinoma', Gynecologic Oncology, vol. 72, no. 3, pp. 387-391. https://doi.org/10.1006/gyno.1998.5288
Kamura, Toshiharu ; Yahata, Hideaki ; Shigematsu, Toshiyuki ; Ogawa, Shinji ; Amada, Satoshi ; Kaku, Tsunehisa ; Nakano, Hitoo. / Predicting pelvic lymph node metastasis in endometrial carcinoma. In: Gynecologic Oncology. 1999 ; Vol. 72, No. 3. pp. 387-391.
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