Prediction of 6-thioguanine nucleotides levels in Japanese patients with inflammatory bowel diseases during long-term thiopurine administration

Shuji Kochi, Takayuki Matsumoto, Motohiro Esaki, Yukihiko Jo, Mitsuo Iida

Research output: Contribution to journalArticle

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Abstract

Background. The monitoring of 6-thioguanine nucleotides (6-TGN) levels is warranted during thiopurine therapy for patients with inflammatory bowel diseases. Aims. The aim of this study was to elucidate the parameters that can predict the 6-TGN levels among Japanese patients with inflammatory bowel diseases undergoing thiopurine therapy. Material and methods. The 6-TGN levels were measured in 54 patients with inflammatory bowel diseases (32 with ulcerative colitis and 22 with Crohn's disease), who had been administered azathioprine or 6-mercaptopurine for more than 90 days. Possible correlations between the hematologic parameters and 6-TGN levels were investigated. The clinical and hematologic variables were evaluated to determine the 6-TGN levels of less than or over 235 pmol/8 × 108 RBCs. Results. The 6-TGN levels correlated significantly with changes in the mean corpuscular volume (R 0.423, p 0.001) and the lymphocyte counts (R-0.280, p 0.04). A multivariate analysis revealed changes in the mean corpuscular volume (OR: 1.22, 95% CI: 1.071.40) and hemoglobin levels (OR: 0.59, 95% CI: 0.350.99) to be factors predictive of the 6-TGN levels. An increase in the mean corpuscular volume of 3.5 fl was determined to be the most preferable cut-off value to distinguish patients with 6-TGN ≥ 235 pmol/8 × 108 RBCs from those with a lower concentration. Conclusions. Changes in the mean corpuscular volume are considered to be predictive of the 6-TGN levels in patients with inflammatory bowel diseases receiving thiopurine therapy.

Original languageEnglish
Pages (from-to)608-614
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume45
Issue number5
DOIs
Publication statusPublished - May 1 2010

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Inflammatory Bowel Diseases
Erythrocyte Indices
6-thioguanylic acid
6-Mercaptopurine
Azathioprine
Lymphocyte Count
Ulcerative Colitis
Crohn Disease
Hemoglobins
Therapeutics
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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Prediction of 6-thioguanine nucleotides levels in Japanese patients with inflammatory bowel diseases during long-term thiopurine administration. / Kochi, Shuji; Matsumoto, Takayuki; Esaki, Motohiro; Jo, Yukihiko; Iida, Mitsuo.

In: Scandinavian Journal of Gastroenterology, Vol. 45, No. 5, 01.05.2010, p. 608-614.

Research output: Contribution to journalArticle

Kochi, Shuji ; Matsumoto, Takayuki ; Esaki, Motohiro ; Jo, Yukihiko ; Iida, Mitsuo. / Prediction of 6-thioguanine nucleotides levels in Japanese patients with inflammatory bowel diseases during long-term thiopurine administration. In: Scandinavian Journal of Gastroenterology. 2010 ; Vol. 45, No. 5. pp. 608-614.
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abstract = "Background. The monitoring of 6-thioguanine nucleotides (6-TGN) levels is warranted during thiopurine therapy for patients with inflammatory bowel diseases. Aims. The aim of this study was to elucidate the parameters that can predict the 6-TGN levels among Japanese patients with inflammatory bowel diseases undergoing thiopurine therapy. Material and methods. The 6-TGN levels were measured in 54 patients with inflammatory bowel diseases (32 with ulcerative colitis and 22 with Crohn's disease), who had been administered azathioprine or 6-mercaptopurine for more than 90 days. Possible correlations between the hematologic parameters and 6-TGN levels were investigated. The clinical and hematologic variables were evaluated to determine the 6-TGN levels of less than or over 235 pmol/8 × 108 RBCs. Results. The 6-TGN levels correlated significantly with changes in the mean corpuscular volume (R 0.423, p 0.001) and the lymphocyte counts (R-0.280, p 0.04). A multivariate analysis revealed changes in the mean corpuscular volume (OR: 1.22, 95{\%} CI: 1.071.40) and hemoglobin levels (OR: 0.59, 95{\%} CI: 0.350.99) to be factors predictive of the 6-TGN levels. An increase in the mean corpuscular volume of 3.5 fl was determined to be the most preferable cut-off value to distinguish patients with 6-TGN ≥ 235 pmol/8 × 108 RBCs from those with a lower concentration. Conclusions. Changes in the mean corpuscular volume are considered to be predictive of the 6-TGN levels in patients with inflammatory bowel diseases receiving thiopurine therapy.",
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N2 - Background. The monitoring of 6-thioguanine nucleotides (6-TGN) levels is warranted during thiopurine therapy for patients with inflammatory bowel diseases. Aims. The aim of this study was to elucidate the parameters that can predict the 6-TGN levels among Japanese patients with inflammatory bowel diseases undergoing thiopurine therapy. Material and methods. The 6-TGN levels were measured in 54 patients with inflammatory bowel diseases (32 with ulcerative colitis and 22 with Crohn's disease), who had been administered azathioprine or 6-mercaptopurine for more than 90 days. Possible correlations between the hematologic parameters and 6-TGN levels were investigated. The clinical and hematologic variables were evaluated to determine the 6-TGN levels of less than or over 235 pmol/8 × 108 RBCs. Results. The 6-TGN levels correlated significantly with changes in the mean corpuscular volume (R 0.423, p 0.001) and the lymphocyte counts (R-0.280, p 0.04). A multivariate analysis revealed changes in the mean corpuscular volume (OR: 1.22, 95% CI: 1.071.40) and hemoglobin levels (OR: 0.59, 95% CI: 0.350.99) to be factors predictive of the 6-TGN levels. An increase in the mean corpuscular volume of 3.5 fl was determined to be the most preferable cut-off value to distinguish patients with 6-TGN ≥ 235 pmol/8 × 108 RBCs from those with a lower concentration. Conclusions. Changes in the mean corpuscular volume are considered to be predictive of the 6-TGN levels in patients with inflammatory bowel diseases receiving thiopurine therapy.

AB - Background. The monitoring of 6-thioguanine nucleotides (6-TGN) levels is warranted during thiopurine therapy for patients with inflammatory bowel diseases. Aims. The aim of this study was to elucidate the parameters that can predict the 6-TGN levels among Japanese patients with inflammatory bowel diseases undergoing thiopurine therapy. Material and methods. The 6-TGN levels were measured in 54 patients with inflammatory bowel diseases (32 with ulcerative colitis and 22 with Crohn's disease), who had been administered azathioprine or 6-mercaptopurine for more than 90 days. Possible correlations between the hematologic parameters and 6-TGN levels were investigated. The clinical and hematologic variables were evaluated to determine the 6-TGN levels of less than or over 235 pmol/8 × 108 RBCs. Results. The 6-TGN levels correlated significantly with changes in the mean corpuscular volume (R 0.423, p 0.001) and the lymphocyte counts (R-0.280, p 0.04). A multivariate analysis revealed changes in the mean corpuscular volume (OR: 1.22, 95% CI: 1.071.40) and hemoglobin levels (OR: 0.59, 95% CI: 0.350.99) to be factors predictive of the 6-TGN levels. An increase in the mean corpuscular volume of 3.5 fl was determined to be the most preferable cut-off value to distinguish patients with 6-TGN ≥ 235 pmol/8 × 108 RBCs from those with a lower concentration. Conclusions. Changes in the mean corpuscular volume are considered to be predictive of the 6-TGN levels in patients with inflammatory bowel diseases receiving thiopurine therapy.

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