Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization

CINC-J study investigators

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background The majority of patients who undergo coronary arteriography are discharged from the hospital on the day of the procedure or on the following day. The aim of this study is to investigate whether the change in serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) on the day following cardiac catheterization can predict the development of contrast-induced nephropathy (CIN). Methods This is a multicenter prospective observational study, which consists of 860 patients who underwent cardiac catheterization. We measured SCr and eGFR before cardiac catheterization, on the following day, and 48–72 h post-procedure. Definition of CIN is changes in SCr ≥0.5 mg/dL or ≥25% from baseline 48–72 h after contrast exposure. Results CIN occurred in 40 patients. SCr levels significantly increased from a baseline of 1.55 ± 1.08 mg/dL to 1.79 ± 1.26 mg/dL on the following day in patients with CIN (p < 0.0001), but significantly decreased from a baseline of 1.21 ± 0.65 mg/dL to 1.18 ± 0.61 mg/dL on the following day in those without CIN (p < 0.0001). eGFR significantly decreased from a baseline of 47.3 ± 28.3 mL/min/1.73 m2 to 40.6 ± 26.7 mL/min/1.73 m2 on the following day in patients with CIN (p < 0.0001), but significantly increased from a baseline of 53.1 ± 22.0 mg/dL to 53.6 ± 21.2 mg/dL on the following day in those without CIN (p = 0.0236). Receiver operating characteristic curve analysis indicated that SCr change ≥0.1 mg/dL [area under the curve (AUC) = 0.852, sensitivity 72.5%, specificity 86.1%] and eGFR change ≤−1.1 mL/min/1.73 m2 (AUC = 0.789, sensitivity 85.0%, specificity 64.9%) were the best cut-off values for predicting CIN. Multivariate logistic regression showed that a change in SCr ≥0.1 mg/dL [odds ratio (OR), 29.3; 95% confidence interval (CI), 10.8–96.2] and change in eGFR ≤−1.1 mL/min/1.73 m2 (OR, 69.7; 95% CI, 13.3–952) were powerful independent predictors of CIN. Conclusions Changes in SCr and eGFR on the day following cardiac catheterization predict the development of CIN.

Original languageEnglish
Pages (from-to)412-418
Number of pages7
JournalJournal of Cardiology
Volume68
Issue number5
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Cardiac Catheterization
Glomerular Filtration Rate
Creatinine
Serum
Area Under Curve
Odds Ratio
Confidence Intervals
Sensitivity and Specificity
ROC Curve
Observational Studies
Angiography
Logistic Models
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization. / CINC-J study investigators.

In: Journal of Cardiology, Vol. 68, No. 5, 01.11.2016, p. 412-418.

Research output: Contribution to journalArticle

@article{7bc0579298304374be84eefa0e9a2d1b,
title = "Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization",
abstract = "Background The majority of patients who undergo coronary arteriography are discharged from the hospital on the day of the procedure or on the following day. The aim of this study is to investigate whether the change in serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) on the day following cardiac catheterization can predict the development of contrast-induced nephropathy (CIN). Methods This is a multicenter prospective observational study, which consists of 860 patients who underwent cardiac catheterization. We measured SCr and eGFR before cardiac catheterization, on the following day, and 48–72 h post-procedure. Definition of CIN is changes in SCr ≥0.5 mg/dL or ≥25{\%} from baseline 48–72 h after contrast exposure. Results CIN occurred in 40 patients. SCr levels significantly increased from a baseline of 1.55 ± 1.08 mg/dL to 1.79 ± 1.26 mg/dL on the following day in patients with CIN (p < 0.0001), but significantly decreased from a baseline of 1.21 ± 0.65 mg/dL to 1.18 ± 0.61 mg/dL on the following day in those without CIN (p < 0.0001). eGFR significantly decreased from a baseline of 47.3 ± 28.3 mL/min/1.73 m2 to 40.6 ± 26.7 mL/min/1.73 m2 on the following day in patients with CIN (p < 0.0001), but significantly increased from a baseline of 53.1 ± 22.0 mg/dL to 53.6 ± 21.2 mg/dL on the following day in those without CIN (p = 0.0236). Receiver operating characteristic curve analysis indicated that SCr change ≥0.1 mg/dL [area under the curve (AUC) = 0.852, sensitivity 72.5{\%}, specificity 86.1{\%}] and eGFR change ≤−1.1 mL/min/1.73 m2 (AUC = 0.789, sensitivity 85.0{\%}, specificity 64.9{\%}) were the best cut-off values for predicting CIN. Multivariate logistic regression showed that a change in SCr ≥0.1 mg/dL [odds ratio (OR), 29.3; 95{\%} confidence interval (CI), 10.8–96.2] and change in eGFR ≤−1.1 mL/min/1.73 m2 (OR, 69.7; 95{\%} CI, 13.3–952) were powerful independent predictors of CIN. Conclusions Changes in SCr and eGFR on the day following cardiac catheterization predict the development of CIN.",
author = "{CINC-J study investigators} and Makoto Watanabe and Yoshihiko Saito and Kazutaka Aonuma and Atsushi Hirayama and Nagara Tamaki and Hiroyuki Tsutsui and Hiroyuki Tsutsui and Hisao Ogawa and Takashi Akasaka and Michihiro Yoshimura and Akira Sato and Tadateru Takayama and Mamoru Sakakibara and Susumu Suzuki and Kenichi Ishigami and Kenji Onoue",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.jjcc.2015.10.016",
language = "English",
volume = "68",
pages = "412--418",
journal = "Journal of Cardiology",
issn = "0914-5087",
number = "5",

}

TY - JOUR

T1 - Prediction of contrast-induced nephropathy by the serum creatinine level on the day following cardiac catheterization

AU - CINC-J study investigators

AU - Watanabe, Makoto

AU - Saito, Yoshihiko

AU - Aonuma, Kazutaka

AU - Hirayama, Atsushi

AU - Tamaki, Nagara

AU - Tsutsui, Hiroyuki

AU - Tsutsui, Hiroyuki

AU - Ogawa, Hisao

AU - Akasaka, Takashi

AU - Yoshimura, Michihiro

AU - Sato, Akira

AU - Takayama, Tadateru

AU - Sakakibara, Mamoru

AU - Suzuki, Susumu

AU - Ishigami, Kenichi

AU - Onoue, Kenji

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background The majority of patients who undergo coronary arteriography are discharged from the hospital on the day of the procedure or on the following day. The aim of this study is to investigate whether the change in serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) on the day following cardiac catheterization can predict the development of contrast-induced nephropathy (CIN). Methods This is a multicenter prospective observational study, which consists of 860 patients who underwent cardiac catheterization. We measured SCr and eGFR before cardiac catheterization, on the following day, and 48–72 h post-procedure. Definition of CIN is changes in SCr ≥0.5 mg/dL or ≥25% from baseline 48–72 h after contrast exposure. Results CIN occurred in 40 patients. SCr levels significantly increased from a baseline of 1.55 ± 1.08 mg/dL to 1.79 ± 1.26 mg/dL on the following day in patients with CIN (p < 0.0001), but significantly decreased from a baseline of 1.21 ± 0.65 mg/dL to 1.18 ± 0.61 mg/dL on the following day in those without CIN (p < 0.0001). eGFR significantly decreased from a baseline of 47.3 ± 28.3 mL/min/1.73 m2 to 40.6 ± 26.7 mL/min/1.73 m2 on the following day in patients with CIN (p < 0.0001), but significantly increased from a baseline of 53.1 ± 22.0 mg/dL to 53.6 ± 21.2 mg/dL on the following day in those without CIN (p = 0.0236). Receiver operating characteristic curve analysis indicated that SCr change ≥0.1 mg/dL [area under the curve (AUC) = 0.852, sensitivity 72.5%, specificity 86.1%] and eGFR change ≤−1.1 mL/min/1.73 m2 (AUC = 0.789, sensitivity 85.0%, specificity 64.9%) were the best cut-off values for predicting CIN. Multivariate logistic regression showed that a change in SCr ≥0.1 mg/dL [odds ratio (OR), 29.3; 95% confidence interval (CI), 10.8–96.2] and change in eGFR ≤−1.1 mL/min/1.73 m2 (OR, 69.7; 95% CI, 13.3–952) were powerful independent predictors of CIN. Conclusions Changes in SCr and eGFR on the day following cardiac catheterization predict the development of CIN.

AB - Background The majority of patients who undergo coronary arteriography are discharged from the hospital on the day of the procedure or on the following day. The aim of this study is to investigate whether the change in serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) on the day following cardiac catheterization can predict the development of contrast-induced nephropathy (CIN). Methods This is a multicenter prospective observational study, which consists of 860 patients who underwent cardiac catheterization. We measured SCr and eGFR before cardiac catheterization, on the following day, and 48–72 h post-procedure. Definition of CIN is changes in SCr ≥0.5 mg/dL or ≥25% from baseline 48–72 h after contrast exposure. Results CIN occurred in 40 patients. SCr levels significantly increased from a baseline of 1.55 ± 1.08 mg/dL to 1.79 ± 1.26 mg/dL on the following day in patients with CIN (p < 0.0001), but significantly decreased from a baseline of 1.21 ± 0.65 mg/dL to 1.18 ± 0.61 mg/dL on the following day in those without CIN (p < 0.0001). eGFR significantly decreased from a baseline of 47.3 ± 28.3 mL/min/1.73 m2 to 40.6 ± 26.7 mL/min/1.73 m2 on the following day in patients with CIN (p < 0.0001), but significantly increased from a baseline of 53.1 ± 22.0 mg/dL to 53.6 ± 21.2 mg/dL on the following day in those without CIN (p = 0.0236). Receiver operating characteristic curve analysis indicated that SCr change ≥0.1 mg/dL [area under the curve (AUC) = 0.852, sensitivity 72.5%, specificity 86.1%] and eGFR change ≤−1.1 mL/min/1.73 m2 (AUC = 0.789, sensitivity 85.0%, specificity 64.9%) were the best cut-off values for predicting CIN. Multivariate logistic regression showed that a change in SCr ≥0.1 mg/dL [odds ratio (OR), 29.3; 95% confidence interval (CI), 10.8–96.2] and change in eGFR ≤−1.1 mL/min/1.73 m2 (OR, 69.7; 95% CI, 13.3–952) were powerful independent predictors of CIN. Conclusions Changes in SCr and eGFR on the day following cardiac catheterization predict the development of CIN.

UR - http://www.scopus.com/inward/record.url?scp=84950145935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950145935&partnerID=8YFLogxK

U2 - 10.1016/j.jjcc.2015.10.016

DO - 10.1016/j.jjcc.2015.10.016

M3 - Article

C2 - 26708123

AN - SCOPUS:84950145935

VL - 68

SP - 412

EP - 418

JO - Journal of Cardiology

JF - Journal of Cardiology

SN - 0914-5087

IS - 5

ER -