Prediction of histological types of endometrial cancer by endometrial cytology

Masao Okadome, Toshiaki Saito, Naoko Nishiyama, Kazuya Ariyoshi, Kumi Shimamoto, Takako Shimada, Keisuke Kodama, Shogo Imamura, Ken Ichi Nishiyama, Kenichi Taguchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low- and high-risk histology in women with endometrial cancer (EC). This single-institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low-risk and high-risk histology of EC. Methods Between January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single-use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest. Results For type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non-endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology (P = 0.002). Conclusion Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.

Original languageEnglish
Pages (from-to)1931-1939
Number of pages9
JournalJournal of Obstetrics and Gynaecology Research
Volume40
Issue number7
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Endometrial Neoplasms
Cell Biology
Biopsy
Histology
Endometrioid Carcinoma
Carcinoma
Suction
Hysterectomy
Plastics
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Okadome, M., Saito, T., Nishiyama, N., Ariyoshi, K., Shimamoto, K., Shimada, T., ... Taguchi, K. (2014). Prediction of histological types of endometrial cancer by endometrial cytology. Journal of Obstetrics and Gynaecology Research, 40(7), 1931-1939. https://doi.org/10.1111/jog.12436

Prediction of histological types of endometrial cancer by endometrial cytology. / Okadome, Masao; Saito, Toshiaki; Nishiyama, Naoko; Ariyoshi, Kazuya; Shimamoto, Kumi; Shimada, Takako; Kodama, Keisuke; Imamura, Shogo; Nishiyama, Ken Ichi; Taguchi, Kenichi.

In: Journal of Obstetrics and Gynaecology Research, Vol. 40, No. 7, 01.01.2014, p. 1931-1939.

Research output: Contribution to journalArticle

Okadome, M, Saito, T, Nishiyama, N, Ariyoshi, K, Shimamoto, K, Shimada, T, Kodama, K, Imamura, S, Nishiyama, KI & Taguchi, K 2014, 'Prediction of histological types of endometrial cancer by endometrial cytology', Journal of Obstetrics and Gynaecology Research, vol. 40, no. 7, pp. 1931-1939. https://doi.org/10.1111/jog.12436
Okadome M, Saito T, Nishiyama N, Ariyoshi K, Shimamoto K, Shimada T et al. Prediction of histological types of endometrial cancer by endometrial cytology. Journal of Obstetrics and Gynaecology Research. 2014 Jan 1;40(7):1931-1939. https://doi.org/10.1111/jog.12436
Okadome, Masao ; Saito, Toshiaki ; Nishiyama, Naoko ; Ariyoshi, Kazuya ; Shimamoto, Kumi ; Shimada, Takako ; Kodama, Keisuke ; Imamura, Shogo ; Nishiyama, Ken Ichi ; Taguchi, Kenichi. / Prediction of histological types of endometrial cancer by endometrial cytology. In: Journal of Obstetrics and Gynaecology Research. 2014 ; Vol. 40, No. 7. pp. 1931-1939.
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abstract = "Aim Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low- and high-risk histology in women with endometrial cancer (EC). This single-institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low-risk and high-risk histology of EC. Methods Between January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single-use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest. Results For type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non-endometrioid histology, biopsy was 67.6{\%} sensitive (25/37) and 84.9{\%} specific (62/73); whereas cytology was 70.3{\%} sensitive (26/37) and 91.8{\%} specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1{\%} (10/110) were unevaluable using biopsy, significantly more than the 0{\%} (0/110) by cytology (P = 0.002). Conclusion Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.",
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AU - Okadome, Masao

AU - Saito, Toshiaki

AU - Nishiyama, Naoko

AU - Ariyoshi, Kazuya

AU - Shimamoto, Kumi

AU - Shimada, Takako

AU - Kodama, Keisuke

AU - Imamura, Shogo

AU - Nishiyama, Ken Ichi

AU - Taguchi, Kenichi

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N2 - Aim Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low- and high-risk histology in women with endometrial cancer (EC). This single-institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low-risk and high-risk histology of EC. Methods Between January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single-use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest. Results For type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non-endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology (P = 0.002). Conclusion Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.

AB - Aim Few studies have examined the accuracy of preoperative endometrial cytology in diagnosing low- and high-risk histology in women with endometrial cancer (EC). This single-institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low-risk and high-risk histology of EC. Methods Between January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single-use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest. Results For type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non-endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology (P = 0.002). Conclusion Although preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.

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