Prediction of outcome with FDG-PET in definitive chemoradiotherapy for esophageal cancer

Kazushige Atsumi, Katsumasa Nakamura, Koichiro Abe, Masakazu Hirakawa, Yoshiyuki Shioyama, Tomonari Sasaki, Shingo Baba, Takuro Isoda, Ohga Saiji, Tadamasa Yoshitake, Makoto Shinoto, Kaori Asai, Hiroshi Honda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The purpose of this study was to assess the efficacy of 18F-fluoro-2-deoxy-glucose uptake positron emission tomography (FDG-PET) for the prediction of outcome in definitive chemoradiotherapy (CRT) for esophageal cancer. We enrolled 56 patients with esophageal cancer treated with definitive CRT and examined by FDG-PET before treatment. We examined the correlation of the maximum standardized uptake value (SUVmax) in FDG-PET of the primary tumor with overall survival (OS), progression-free survival (PFS), local control (LC) and response of the primary tumor. After definitive CRT, 30 patients had a clinical complete response (CR), making the CR rate 54%. For all 56 patients, the 2-year OS rate, PFS rate and LC rates were 64%, 38% and 51%, respectively. We divided the patients into two groups according to SUVmax: SUVmax < 10 (low-SUV) and <10 (high-SUV). The 2-year OS rates in the low- and high-SUV groups were 100% and 41%, the PFS rates were 73% and 19%, the LC rates were 71% and 39%, and the CR rates were 100% and 32%, respectively. A univariate analysis revealed significant differences between the low- and high-SUV group in OS, PFS, LC and response (P = 0.0005, 0.0002, 0.048, and <0.0001, respectively). SUVmax and T stage were significantly associated with OS, PFS, LC and response. A multivariate analysis showed significant differences between the SUVmax <10 and ≥10 groups in overall survival and response (P < 0.05). Our result suggests that the SUVmax in FDG-PET of the primary tumor before treatment may have prognostic value for esophageal cancer.

Original languageEnglish
Pages (from-to)890-898
Number of pages9
JournalJournal of radiation research
Volume54
Issue number5
DOIs
Publication statusPublished - Sep 1 2013

Fingerprint

Chemoradiotherapy
Esophageal Neoplasms
glucose
Positron-Emission Tomography
Disease-Free Survival
positrons
tomography
cancer
Glucose
Survival Rate
predictions
Survival
progressions
Neoplasms
tumors
Multivariate Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Prediction of outcome with FDG-PET in definitive chemoradiotherapy for esophageal cancer. / Atsumi, Kazushige; Nakamura, Katsumasa; Abe, Koichiro; Hirakawa, Masakazu; Shioyama, Yoshiyuki; Sasaki, Tomonari; Baba, Shingo; Isoda, Takuro; Saiji, Ohga; Yoshitake, Tadamasa; Shinoto, Makoto; Asai, Kaori; Honda, Hiroshi.

In: Journal of radiation research, Vol. 54, No. 5, 01.09.2013, p. 890-898.

Research output: Contribution to journalArticle

@article{b24d9d0360a14ca68efb82c893256612,
title = "Prediction of outcome with FDG-PET in definitive chemoradiotherapy for esophageal cancer",
abstract = "The purpose of this study was to assess the efficacy of 18F-fluoro-2-deoxy-glucose uptake positron emission tomography (FDG-PET) for the prediction of outcome in definitive chemoradiotherapy (CRT) for esophageal cancer. We enrolled 56 patients with esophageal cancer treated with definitive CRT and examined by FDG-PET before treatment. We examined the correlation of the maximum standardized uptake value (SUVmax) in FDG-PET of the primary tumor with overall survival (OS), progression-free survival (PFS), local control (LC) and response of the primary tumor. After definitive CRT, 30 patients had a clinical complete response (CR), making the CR rate 54{\%}. For all 56 patients, the 2-year OS rate, PFS rate and LC rates were 64{\%}, 38{\%} and 51{\%}, respectively. We divided the patients into two groups according to SUVmax: SUVmax < 10 (low-SUV) and <10 (high-SUV). The 2-year OS rates in the low- and high-SUV groups were 100{\%} and 41{\%}, the PFS rates were 73{\%} and 19{\%}, the LC rates were 71{\%} and 39{\%}, and the CR rates were 100{\%} and 32{\%}, respectively. A univariate analysis revealed significant differences between the low- and high-SUV group in OS, PFS, LC and response (P = 0.0005, 0.0002, 0.048, and <0.0001, respectively). SUVmax and T stage were significantly associated with OS, PFS, LC and response. A multivariate analysis showed significant differences between the SUVmax <10 and ≥10 groups in overall survival and response (P < 0.05). Our result suggests that the SUVmax in FDG-PET of the primary tumor before treatment may have prognostic value for esophageal cancer.",
author = "Kazushige Atsumi and Katsumasa Nakamura and Koichiro Abe and Masakazu Hirakawa and Yoshiyuki Shioyama and Tomonari Sasaki and Shingo Baba and Takuro Isoda and Ohga Saiji and Tadamasa Yoshitake and Makoto Shinoto and Kaori Asai and Hiroshi Honda",
year = "2013",
month = "9",
day = "1",
doi = "10.1093/jrr/rrt021",
language = "English",
volume = "54",
pages = "890--898",
journal = "Journal of Radiation Research",
issn = "0449-3060",
publisher = "Japan Radiation Research Society",
number = "5",

}

TY - JOUR

T1 - Prediction of outcome with FDG-PET in definitive chemoradiotherapy for esophageal cancer

AU - Atsumi, Kazushige

AU - Nakamura, Katsumasa

AU - Abe, Koichiro

AU - Hirakawa, Masakazu

AU - Shioyama, Yoshiyuki

AU - Sasaki, Tomonari

AU - Baba, Shingo

AU - Isoda, Takuro

AU - Saiji, Ohga

AU - Yoshitake, Tadamasa

AU - Shinoto, Makoto

AU - Asai, Kaori

AU - Honda, Hiroshi

PY - 2013/9/1

Y1 - 2013/9/1

N2 - The purpose of this study was to assess the efficacy of 18F-fluoro-2-deoxy-glucose uptake positron emission tomography (FDG-PET) for the prediction of outcome in definitive chemoradiotherapy (CRT) for esophageal cancer. We enrolled 56 patients with esophageal cancer treated with definitive CRT and examined by FDG-PET before treatment. We examined the correlation of the maximum standardized uptake value (SUVmax) in FDG-PET of the primary tumor with overall survival (OS), progression-free survival (PFS), local control (LC) and response of the primary tumor. After definitive CRT, 30 patients had a clinical complete response (CR), making the CR rate 54%. For all 56 patients, the 2-year OS rate, PFS rate and LC rates were 64%, 38% and 51%, respectively. We divided the patients into two groups according to SUVmax: SUVmax < 10 (low-SUV) and <10 (high-SUV). The 2-year OS rates in the low- and high-SUV groups were 100% and 41%, the PFS rates were 73% and 19%, the LC rates were 71% and 39%, and the CR rates were 100% and 32%, respectively. A univariate analysis revealed significant differences between the low- and high-SUV group in OS, PFS, LC and response (P = 0.0005, 0.0002, 0.048, and <0.0001, respectively). SUVmax and T stage were significantly associated with OS, PFS, LC and response. A multivariate analysis showed significant differences between the SUVmax <10 and ≥10 groups in overall survival and response (P < 0.05). Our result suggests that the SUVmax in FDG-PET of the primary tumor before treatment may have prognostic value for esophageal cancer.

AB - The purpose of this study was to assess the efficacy of 18F-fluoro-2-deoxy-glucose uptake positron emission tomography (FDG-PET) for the prediction of outcome in definitive chemoradiotherapy (CRT) for esophageal cancer. We enrolled 56 patients with esophageal cancer treated with definitive CRT and examined by FDG-PET before treatment. We examined the correlation of the maximum standardized uptake value (SUVmax) in FDG-PET of the primary tumor with overall survival (OS), progression-free survival (PFS), local control (LC) and response of the primary tumor. After definitive CRT, 30 patients had a clinical complete response (CR), making the CR rate 54%. For all 56 patients, the 2-year OS rate, PFS rate and LC rates were 64%, 38% and 51%, respectively. We divided the patients into two groups according to SUVmax: SUVmax < 10 (low-SUV) and <10 (high-SUV). The 2-year OS rates in the low- and high-SUV groups were 100% and 41%, the PFS rates were 73% and 19%, the LC rates were 71% and 39%, and the CR rates were 100% and 32%, respectively. A univariate analysis revealed significant differences between the low- and high-SUV group in OS, PFS, LC and response (P = 0.0005, 0.0002, 0.048, and <0.0001, respectively). SUVmax and T stage were significantly associated with OS, PFS, LC and response. A multivariate analysis showed significant differences between the SUVmax <10 and ≥10 groups in overall survival and response (P < 0.05). Our result suggests that the SUVmax in FDG-PET of the primary tumor before treatment may have prognostic value for esophageal cancer.

UR - http://www.scopus.com/inward/record.url?scp=84888211453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888211453&partnerID=8YFLogxK

U2 - 10.1093/jrr/rrt021

DO - 10.1093/jrr/rrt021

M3 - Article

VL - 54

SP - 890

EP - 898

JO - Journal of Radiation Research

JF - Journal of Radiation Research

SN - 0449-3060

IS - 5

ER -