Prediction of prognosis in LEC rats with fulminant hepatitis

Nobuaki Nakayama, Haruhiko Kashiwazaki, Narumi Kobayashi, Noritoshi Takeichi, Jong hong Kang, Yasushi Itakura, Kunio Matsumoto, Toshikazu Nakamura, Takao Koike, Nobuaki Nakayama

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Abstract

We investigated possibility of predicting prognosis in LEC rats with fulminant hepatitis, using various biochemical and hematological parameters. Nine of 20 rats used in this study died of fulminant hepatitis. The plasma HGF levels were high in rats with fulminant hepatitis. The multivariate analysis using biochemical and hematological data at 16 weeks of age and the surviving rate showed that serum alkaline phosphatase (ALP) is the most reliable parameter for predicting fulminant hapatitis. The higher the serum ALP levels were, the better the prognoses of LEC rats with fulminant hepatitis were. According to references, we suggest the serum ALP levels may reflect the regeneration of the liver. Therefore, it may be possible to monitor the regeneration of hepatocytes and to predict fulminant hepatitis by measuring both serum ALP and plasma (serum) HGF which promotes proliferation of hepatocytes.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalKanzo
Volume35
Issue number5
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Nakayama, N., Kashiwazaki, H., Kobayashi, N., Takeichi, N., Kang, J. H., Itakura, Y., ... Nakayama, N. (1994). Prediction of prognosis in LEC rats with fulminant hepatitis. Kanzo, 35(5), 363-369. https://doi.org/10.2957/kanzo.35.363