Prediction of prognosis in LEC rats with fulminant hepatitis

Nobuaki Nakayama; Haruhiko Kashiwazaki; Narumi Kobayashi; Noritoshi Takeichi; Jong hong Kang; Yasushi Itakura; Kunio Matsumoto; Toshikazu Nakamura; Takao Koike; Nobuaki Nakayama

doi:10.2957/kanzo.35.363

Prediction of prognosis in LEC rats with fulminant hepatitis

Nobuaki Nakayama, Haruhiko Kashiwazaki, Narumi Kobayashi, Noritoshi Takeichi, Jong hong Kang, Yasushi Itakura, Kunio Matsumoto, Toshikazu Nakamura, Takao Koike, Nobuaki Nakayama

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Abstract

We investigated possibility of predicting prognosis in LEC rats with fulminant hepatitis, using various biochemical and hematological parameters. Nine of 20 rats used in this study died of fulminant hepatitis. The plasma HGF levels were high in rats with fulminant hepatitis. The multivariate analysis using biochemical and hematological data at 16 weeks of age and the surviving rate showed that serum alkaline phosphatase (ALP) is the most reliable parameter for predicting fulminant hapatitis. The higher the serum ALP levels were, the better the prognoses of LEC rats with fulminant hepatitis were. According to references, we suggest the serum ALP levels may reflect the regeneration of the liver. Therefore, it may be possible to monitor the regeneration of hepatocytes and to predict fulminant hepatitis by measuring both serum ALP and plasma (serum) HGF which promotes proliferation of hepatocytes.

Original language	English
Pages (from-to)	363-369
Number of pages	7
Journal	Kanzo
Volume	35
Issue number	5
DOIs	https://doi.org/10.2957/kanzo.35.363
Publication status	Published - Jan 1 1994
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Hepatology

Cite this

Nakayama, N., Kashiwazaki, H., Kobayashi, N., Takeichi, N., Kang, J. H., Itakura, Y., ... Nakayama, N. (1994). Prediction of prognosis in LEC rats with fulminant hepatitis. Kanzo, 35(5), 363-369. https://doi.org/10.2957/kanzo.35.363

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abstract = "We investigated possibility of predicting prognosis in LEC rats with fulminant hepatitis, using various biochemical and hematological parameters. Nine of 20 rats used in this study died of fulminant hepatitis. The plasma HGF levels were high in rats with fulminant hepatitis. The multivariate analysis using biochemical and hematological data at 16 weeks of age and the surviving rate showed that serum alkaline phosphatase (ALP) is the most reliable parameter for predicting fulminant hapatitis. The higher the serum ALP levels were, the better the prognoses of LEC rats with fulminant hepatitis were. According to references, we suggest the serum ALP levels may reflect the regeneration of the liver. Therefore, it may be possible to monitor the regeneration of hepatocytes and to predict fulminant hepatitis by measuring both serum ALP and plasma (serum) HGF which promotes proliferation of hepatocytes.",

author = "Nobuaki Nakayama and Haruhiko Kashiwazaki and Narumi Kobayashi and Noritoshi Takeichi and Kang, {Jong hong} and Yasushi Itakura and Kunio Matsumoto and Toshikazu Nakamura and Takao Koike and Nobuaki Nakayama",

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AU - Nakayama, Nobuaki

AU - Kashiwazaki, Haruhiko

AU - Kobayashi, Narumi

AU - Takeichi, Noritoshi

AU - Kang, Jong hong

AU - Itakura, Yasushi

AU - Matsumoto, Kunio

AU - Nakamura, Toshikazu

AU - Koike, Takao

AU - Nakayama, Nobuaki

PY - 1994/1/1

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AB - We investigated possibility of predicting prognosis in LEC rats with fulminant hepatitis, using various biochemical and hematological parameters. Nine of 20 rats used in this study died of fulminant hepatitis. The plasma HGF levels were high in rats with fulminant hepatitis. The multivariate analysis using biochemical and hematological data at 16 weeks of age and the surviving rate showed that serum alkaline phosphatase (ALP) is the most reliable parameter for predicting fulminant hapatitis. The higher the serum ALP levels were, the better the prognoses of LEC rats with fulminant hepatitis were. According to references, we suggest the serum ALP levels may reflect the regeneration of the liver. Therefore, it may be possible to monitor the regeneration of hepatocytes and to predict fulminant hepatitis by measuring both serum ALP and plasma (serum) HGF which promotes proliferation of hepatocytes.

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10.2957/kanzo.35.363