Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke

Koji Tanaka, Takeshi Yamada, Takako Torii, Shoji Matsumoto, Takeo Yoshimura, Kei Ichiro Takase, Yoshifumi Wakata, Naoki Nakashima, Jun-Ichi Kira, Hiroyuki Murai

Research output: Contribution to journalArticle

Abstract

Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalEuropean Neurology
Volume76
Issue number3-4
DOIs
Publication statusPublished - Oct 1 2016

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Atrial Fibrillation
Stroke
National Institutes of Health (U.S.)
Observational Studies
Myocardial Ischemia
Heart Failure
Retrospective Studies
Databases
Hypertension

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Tanaka, K., Yamada, T., Torii, T., Matsumoto, S., Yoshimura, T., Takase, K. I., ... Murai, H. (2016). Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke. European Neurology, 76(3-4), 105-111. https://doi.org/10.1159/000447629

Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke. / Tanaka, Koji; Yamada, Takeshi; Torii, Takako; Matsumoto, Shoji; Yoshimura, Takeo; Takase, Kei Ichiro; Wakata, Yoshifumi; Nakashima, Naoki; Kira, Jun-Ichi; Murai, Hiroyuki.

In: European Neurology, Vol. 76, No. 3-4, 01.10.2016, p. 105-111.

Research output: Contribution to journalArticle

Tanaka, Koji ; Yamada, Takeshi ; Torii, Takako ; Matsumoto, Shoji ; Yoshimura, Takeo ; Takase, Kei Ichiro ; Wakata, Yoshifumi ; Nakashima, Naoki ; Kira, Jun-Ichi ; Murai, Hiroyuki. / Predictive Factors for Excellent or Extremely Poor Functional Outcome in Initial Atrial Fibrillation-Related Cardioembolic Stroke. In: European Neurology. 2016 ; Vol. 76, No. 3-4. pp. 105-111.
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AU - Tanaka, Koji

AU - Yamada, Takeshi

AU - Torii, Takako

AU - Matsumoto, Shoji

AU - Yoshimura, Takeo

AU - Takase, Kei Ichiro

AU - Wakata, Yoshifumi

AU - Nakashima, Naoki

AU - Kira, Jun-Ichi

AU - Murai, Hiroyuki

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N2 - Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.

AB - Background: We aimed to determine the predictive factors for excellent or extremely poor functional outcome in patients with first-ever atrial fibrillation (AF)-related cardioembolic stroke. Methods: Retrospective observational study from a database. Patients with AF-related cardioembolic stroke with a premorbid modified Rankin Scale (mRS) score of 0 or 1 and without a previous history of stroke were included. Results: Factors associated with excellent functional outcome (mRS scores of 0 or 1; n = 77; 30.4% of patients) included age >78 years (OR 0.31, 95% CI 0.15-0.61), male sex (OR 2.16, 95% CI 1.04-4.60), absence of hypertension (OR 0.46, 95% CI 0.22-0.94) and initial National Institutes of Health Stroke Scale (NIHSS) score of >9 (OR 0.08, 95% CI 0.03-0.16). Factors associated with extremely poor functional outcome (mRS scores of 5 or 6; n = 63; 24.9%) included age >78 years (OR 3.30, 95% CI 1.54-7.39), initial NIHSS score of >9 (OR 12.38, 95% CI 5.40-32.56), congestive heart failure (OR 4.82, 95% CI 2.00-12.19) and ischemic heart disease (OR 4.02, 95% CI 1.18-14.69). Conclusions: Predictive factors exist to delineate excellent and extremely poor functional outcomes after a first-time stroke associated with AF.

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