Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: The Fukuoka Stroke Registry

Takahiro Kuwashiro, Hiroshi Sugimori, Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Takanari Kitazono

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. Design: A prospective cohort study. Setting: Multicentre study at the Fukuoka prefecture in Japan. Participants: We enroled 2084 consecutive patients who were hospitalised in stroke centres within 7 days of onset from June 2007 to October 2009. The clinical characteristics of patients were assessed on admission, and the clinical course of all patients was followed for 1 year. Results: Of all patients, 425 (234 men, 76±11 years of age) had cardioembolic stroke and were included in this study. Fifty-one patients (12%) suffered a recurrence during the follow-up period. Age (HR 1.04, 95% CI 1.01 to 1.06, p=0.014), and level of C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.018) on admission were significantly associated with recurrence in the univariate analyses. Male gender (HR 0.61, 95% CI 0.35 to 1.05, p=0.076), body mass index (HR 0.94, 95% CI 0.87 to 1.01, p=0.093), hypertension (HR 0.59, 95% CI 0.33 to 1.06, p=0.079), diastolic blood pressure (HR 0.99, 95% CI 0.97 to 1.00, p=0.087) and haematocrit (HR 0.95, 95% CI 0.91 to 1.00, p=0.052) were marginally significant in the univariate Cox analyses. Multivariate Cox proportional hazards analysis showed that age (HR 1.03, 95% CI 1.00 to 1. 06, p=0.031, per 1-year increase), and C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.022, per 1 mg/L increase) were independent predictors of a recurrence in the first year after cardioembolic stroke. Conclusions: In patients with cardioembolic ischaemic stroke, age and C reactive protein are independent risk factors for recurrence in the first year after onset.

Original languageEnglish
Article number4
JournalBMJ Open
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 27 2013

Fingerprint

C-Reactive Protein
Registries
Stroke
Recurrence
Blood Pressure
Hematocrit
Multicenter Studies
Japan
Body Mass Index
Cohort Studies
Prospective Studies
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke : The Fukuoka Stroke Registry. / Kuwashiro, Takahiro; Sugimori, Hiroshi; Ago, Tetsuro; Kuroda, Junya; Kamouchi, Masahiro; Kitazono, Takanari.

In: BMJ Open, Vol. 3, No. 11, 4, 27.11.2013.

Research output: Contribution to journalArticle

@article{467c86d61b554677a3b2a98f735cae26,
title = "Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: The Fukuoka Stroke Registry",
abstract = "Objectives: We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. Design: A prospective cohort study. Setting: Multicentre study at the Fukuoka prefecture in Japan. Participants: We enroled 2084 consecutive patients who were hospitalised in stroke centres within 7 days of onset from June 2007 to October 2009. The clinical characteristics of patients were assessed on admission, and the clinical course of all patients was followed for 1 year. Results: Of all patients, 425 (234 men, 76±11 years of age) had cardioembolic stroke and were included in this study. Fifty-one patients (12{\%}) suffered a recurrence during the follow-up period. Age (HR 1.04, 95{\%} CI 1.01 to 1.06, p=0.014), and level of C reactive protein (HR 1.01, 95{\%} CI 1.00 to 1.02, p=0.018) on admission were significantly associated with recurrence in the univariate analyses. Male gender (HR 0.61, 95{\%} CI 0.35 to 1.05, p=0.076), body mass index (HR 0.94, 95{\%} CI 0.87 to 1.01, p=0.093), hypertension (HR 0.59, 95{\%} CI 0.33 to 1.06, p=0.079), diastolic blood pressure (HR 0.99, 95{\%} CI 0.97 to 1.00, p=0.087) and haematocrit (HR 0.95, 95{\%} CI 0.91 to 1.00, p=0.052) were marginally significant in the univariate Cox analyses. Multivariate Cox proportional hazards analysis showed that age (HR 1.03, 95{\%} CI 1.00 to 1. 06, p=0.031, per 1-year increase), and C reactive protein (HR 1.01, 95{\%} CI 1.00 to 1.02, p=0.022, per 1 mg/L increase) were independent predictors of a recurrence in the first year after cardioembolic stroke. Conclusions: In patients with cardioembolic ischaemic stroke, age and C reactive protein are independent risk factors for recurrence in the first year after onset.",
author = "Takahiro Kuwashiro and Hiroshi Sugimori and Tetsuro Ago and Junya Kuroda and Masahiro Kamouchi and Takanari Kitazono",
year = "2013",
month = "11",
day = "27",
doi = "10.1136/bmjopen-2013-003678",
language = "English",
volume = "3",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "11",

}

TY - JOUR

T1 - Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke

T2 - The Fukuoka Stroke Registry

AU - Kuwashiro, Takahiro

AU - Sugimori, Hiroshi

AU - Ago, Tetsuro

AU - Kuroda, Junya

AU - Kamouchi, Masahiro

AU - Kitazono, Takanari

PY - 2013/11/27

Y1 - 2013/11/27

N2 - Objectives: We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. Design: A prospective cohort study. Setting: Multicentre study at the Fukuoka prefecture in Japan. Participants: We enroled 2084 consecutive patients who were hospitalised in stroke centres within 7 days of onset from June 2007 to October 2009. The clinical characteristics of patients were assessed on admission, and the clinical course of all patients was followed for 1 year. Results: Of all patients, 425 (234 men, 76±11 years of age) had cardioembolic stroke and were included in this study. Fifty-one patients (12%) suffered a recurrence during the follow-up period. Age (HR 1.04, 95% CI 1.01 to 1.06, p=0.014), and level of C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.018) on admission were significantly associated with recurrence in the univariate analyses. Male gender (HR 0.61, 95% CI 0.35 to 1.05, p=0.076), body mass index (HR 0.94, 95% CI 0.87 to 1.01, p=0.093), hypertension (HR 0.59, 95% CI 0.33 to 1.06, p=0.079), diastolic blood pressure (HR 0.99, 95% CI 0.97 to 1.00, p=0.087) and haematocrit (HR 0.95, 95% CI 0.91 to 1.00, p=0.052) were marginally significant in the univariate Cox analyses. Multivariate Cox proportional hazards analysis showed that age (HR 1.03, 95% CI 1.00 to 1. 06, p=0.031, per 1-year increase), and C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.022, per 1 mg/L increase) were independent predictors of a recurrence in the first year after cardioembolic stroke. Conclusions: In patients with cardioembolic ischaemic stroke, age and C reactive protein are independent risk factors for recurrence in the first year after onset.

AB - Objectives: We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. Design: A prospective cohort study. Setting: Multicentre study at the Fukuoka prefecture in Japan. Participants: We enroled 2084 consecutive patients who were hospitalised in stroke centres within 7 days of onset from June 2007 to October 2009. The clinical characteristics of patients were assessed on admission, and the clinical course of all patients was followed for 1 year. Results: Of all patients, 425 (234 men, 76±11 years of age) had cardioembolic stroke and were included in this study. Fifty-one patients (12%) suffered a recurrence during the follow-up period. Age (HR 1.04, 95% CI 1.01 to 1.06, p=0.014), and level of C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.018) on admission were significantly associated with recurrence in the univariate analyses. Male gender (HR 0.61, 95% CI 0.35 to 1.05, p=0.076), body mass index (HR 0.94, 95% CI 0.87 to 1.01, p=0.093), hypertension (HR 0.59, 95% CI 0.33 to 1.06, p=0.079), diastolic blood pressure (HR 0.99, 95% CI 0.97 to 1.00, p=0.087) and haematocrit (HR 0.95, 95% CI 0.91 to 1.00, p=0.052) were marginally significant in the univariate Cox analyses. Multivariate Cox proportional hazards analysis showed that age (HR 1.03, 95% CI 1.00 to 1. 06, p=0.031, per 1-year increase), and C reactive protein (HR 1.01, 95% CI 1.00 to 1.02, p=0.022, per 1 mg/L increase) were independent predictors of a recurrence in the first year after cardioembolic stroke. Conclusions: In patients with cardioembolic ischaemic stroke, age and C reactive protein are independent risk factors for recurrence in the first year after onset.

UR - http://www.scopus.com/inward/record.url?scp=84888092729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888092729&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2013-003678

DO - 10.1136/bmjopen-2013-003678

M3 - Article

C2 - 24231460

AN - SCOPUS:84888092729

VL - 3

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 11

M1 - 4

ER -