Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization

Teruhiko Kozuka, Kazuma Ikeda, Takanori Teshima, Kensuke Kojima, Keitaro Matsuo, Akihiro Bessho, Kazutaka Sunami, Yasushi Hiramatsu, Yoshinobu Maeda, Toshio Noguchi, Kazuhiko Yamamoto, Nobuharu Fujii, Toshi Imai, Katsuto Takenaka, Katsuji Shinagawa, Fumihiko Ishimaru, Kenji Niiya, Norio Koide, Mitsune Tanimoto, Mine Harada

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Enumeration of CD34+ cells in peripheral blood (PB) before apheresis predicts the number of CD34+ cells collected, although flow cytometric techniques used are complex and expensive. In an attempt to determine the optimal timing for peripheral blood progenitor cell (PBPC) collection, the usefulness of circulating immature cell (CIC) counts in PB was evaluated. STUDY DESIGN AND METHODS: CIC counts in PB and CD34+ cell counts in the apheresis product from 249 collections were assessed, and the relationship between these two parameters was evaluated by with the Pearson rank correlation analysis, the Fisher exact test, and the U-test. RESULTS: CIC counts were correlated significantly with the number of CD34+ cells per kg of patient's body weight in the apheresis product (Pearson rank correlation analysis: r = 0.635, p < 0.0001). When a level of 1 x 10(9) CICs per L was selected as a cutoff value, the sensitivity and specificity for collecting more than 1 x 10(6) CD34+ cells per kg of body weight were 75.7 and 85.5 percent, respectively. CONCLUSION: The present study strongly suggests that the number of CICs in PB may estimate the number of CD34+ cells collected. The data indicate that CIC counts above 1 x 10(9) per L can be used as a good predictor for PBPC collections containing more than 1 x 10(6) CD34+ cells per kg of body weight in a single apheresis procedure.

Original languageEnglish
Pages (from-to)1514-1522
Number of pages9
JournalTransfusion
Volume42
Issue number11
DOIs
Publication statusPublished - Jan 1 2002

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Granulocyte Colony-Stimulating Factor
Blood Cells
Stem Cells
Cell Count
Blood Component Removal
Drug Therapy
Body Weight
Blood Cell Count
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization. / Kozuka, Teruhiko; Ikeda, Kazuma; Teshima, Takanori; Kojima, Kensuke; Matsuo, Keitaro; Bessho, Akihiro; Sunami, Kazutaka; Hiramatsu, Yasushi; Maeda, Yoshinobu; Noguchi, Toshio; Yamamoto, Kazuhiko; Fujii, Nobuharu; Imai, Toshi; Takenaka, Katsuto; Shinagawa, Katsuji; Ishimaru, Fumihiko; Niiya, Kenji; Koide, Norio; Tanimoto, Mitsune; Harada, Mine.

In: Transfusion, Vol. 42, No. 11, 01.01.2002, p. 1514-1522.

Research output: Contribution to journalArticle

Kozuka, T, Ikeda, K, Teshima, T, Kojima, K, Matsuo, K, Bessho, A, Sunami, K, Hiramatsu, Y, Maeda, Y, Noguchi, T, Yamamoto, K, Fujii, N, Imai, T, Takenaka, K, Shinagawa, K, Ishimaru, F, Niiya, K, Koide, N, Tanimoto, M & Harada, M 2002, 'Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization', Transfusion, vol. 42, no. 11, pp. 1514-1522. https://doi.org/10.1046/j.1537-2995.2002.00218.x
Kozuka, Teruhiko ; Ikeda, Kazuma ; Teshima, Takanori ; Kojima, Kensuke ; Matsuo, Keitaro ; Bessho, Akihiro ; Sunami, Kazutaka ; Hiramatsu, Yasushi ; Maeda, Yoshinobu ; Noguchi, Toshio ; Yamamoto, Kazuhiko ; Fujii, Nobuharu ; Imai, Toshi ; Takenaka, Katsuto ; Shinagawa, Katsuji ; Ishimaru, Fumihiko ; Niiya, Kenji ; Koide, Norio ; Tanimoto, Mitsune ; Harada, Mine. / Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization. In: Transfusion. 2002 ; Vol. 42, No. 11. pp. 1514-1522.
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T1 - Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization

AU - Kozuka, Teruhiko

AU - Ikeda, Kazuma

AU - Teshima, Takanori

AU - Kojima, Kensuke

AU - Matsuo, Keitaro

AU - Bessho, Akihiro

AU - Sunami, Kazutaka

AU - Hiramatsu, Yasushi

AU - Maeda, Yoshinobu

AU - Noguchi, Toshio

AU - Yamamoto, Kazuhiko

AU - Fujii, Nobuharu

AU - Imai, Toshi

AU - Takenaka, Katsuto

AU - Shinagawa, Katsuji

AU - Ishimaru, Fumihiko

AU - Niiya, Kenji

AU - Koide, Norio

AU - Tanimoto, Mitsune

AU - Harada, Mine

PY - 2002/1/1

Y1 - 2002/1/1

N2 - BACKGROUND: Enumeration of CD34+ cells in peripheral blood (PB) before apheresis predicts the number of CD34+ cells collected, although flow cytometric techniques used are complex and expensive. In an attempt to determine the optimal timing for peripheral blood progenitor cell (PBPC) collection, the usefulness of circulating immature cell (CIC) counts in PB was evaluated. STUDY DESIGN AND METHODS: CIC counts in PB and CD34+ cell counts in the apheresis product from 249 collections were assessed, and the relationship between these two parameters was evaluated by with the Pearson rank correlation analysis, the Fisher exact test, and the U-test. RESULTS: CIC counts were correlated significantly with the number of CD34+ cells per kg of patient's body weight in the apheresis product (Pearson rank correlation analysis: r = 0.635, p < 0.0001). When a level of 1 x 10(9) CICs per L was selected as a cutoff value, the sensitivity and specificity for collecting more than 1 x 10(6) CD34+ cells per kg of body weight were 75.7 and 85.5 percent, respectively. CONCLUSION: The present study strongly suggests that the number of CICs in PB may estimate the number of CD34+ cells collected. The data indicate that CIC counts above 1 x 10(9) per L can be used as a good predictor for PBPC collections containing more than 1 x 10(6) CD34+ cells per kg of body weight in a single apheresis procedure.

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