Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer

Yoshihiro Kakeji, Daisuke Korenaga, Shunichi Tsujitani, Musarti Haraguchi, Yoshihiko Machara, Keizo Sugimachi

Research output: Contribution to journalArticle

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Abstract

Proliferative activities in 91 primary gastric carcinomas and 36 corresponding metastatic perigastric lymph nodes were investigated using Ki-67 labeling percentage and an argyrophilic nucleolar organizer region (AgNOR) count. Tumors with a high proliferate activity often metastasized to lymph nodes, and the proliferate activities of the primary lesion and the perigastric lymph node metastaseswere similar. A signif icant correlation was recognized between the Ki-67 labeling percentage and the AgNOR count (r = 0.744; P < 0.001). The Ki-67 labeling percentage and AgNOR count proved to be useful predictors of nodal metastasis regardless of tumor size, depth of invasion, and histological type. Even when tumors are smaller (<7 cm) or the stage of the disease is early (pTl, 2), the formation of metastasis increased with an increased Ki-67 labeling percentage or AgNOR count. The combination analysis of depth of invasion with Ki-67 labeling percentage or AgNOR count gives a more precise prediction of nodal metastasis, compared with histological analysis alone.

Original languageEnglish
Pages (from-to)3503-3506
Number of pages4
JournalCancer Research
Volume51
Issue number13
Publication statusPublished - Jul 1 1991

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Nucleolus Organizer Region
Stomach Neoplasms
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis
Neoplasms
Stomach
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kakeji, Y., Korenaga, D., Tsujitani, S., Haraguchi, M., Machara, Y., & Sugimachi, K. (1991). Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer. Cancer Research, 51(13), 3503-3506.

Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer. / Kakeji, Yoshihiro; Korenaga, Daisuke; Tsujitani, Shunichi; Haraguchi, Musarti; Machara, Yoshihiko; Sugimachi, Keizo.

In: Cancer Research, Vol. 51, No. 13, 01.07.1991, p. 3503-3506.

Research output: Contribution to journalArticle

Kakeji, Y, Korenaga, D, Tsujitani, S, Haraguchi, M, Machara, Y & Sugimachi, K 1991, 'Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer', Cancer Research, vol. 51, no. 13, pp. 3503-3506.
Kakeji Y, Korenaga D, Tsujitani S, Haraguchi M, Machara Y, Sugimachi K. Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer. Cancer Research. 1991 Jul 1;51(13):3503-3506.
Kakeji, Yoshihiro ; Korenaga, Daisuke ; Tsujitani, Shunichi ; Haraguchi, Musarti ; Machara, Yoshihiko ; Sugimachi, Keizo. / Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer. In: Cancer Research. 1991 ; Vol. 51, No. 13. pp. 3503-3506.
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