Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer: A mutivariate analysis

Yoshihiko Maehar, Tetsuya Kusumoto, Ikuo Takahashi, Yoshihiro Kakeji, Hideo Baba, Kouhei Akazawa, Keizo Sugimachi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Serum carcinoembryonic antigen (CEA) levels were determined preoperatively in 221 patients with well-differentiated gastric cancer. The mean preoperative serum CEA level was 15.9 ± 88.5 ng/ml (1.0-1,133.0 ng/ml) for all patients, and the incidence of an elevated CEA (>5 ng/ml) was 11.8% (26/221). The CEA-positive patients had larger tumors, a more prominent serosal invasion, more frequent lymphatic and vascular involvement, less expansive tumor growth and higher rates of lymph node and hepatic metastases than did the CEA-negative patients. Thus, the CEA-positive patients had a more advanced stage of disease, and 61.5% underwent noncurative resection (vs. 11.3% in CEA-negative patients). The survival rate of the CEA-positive patients was lower than that of the CEA-negative ones (p < 0.01). As the multivariate analysis revealed the preoperative CEA level to be an independent prognostic factor for survival, an assay for this antigen prior to surgery is to be recommended.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalOncology (Switzerland)
Volume51
Issue number3
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

Carcinoembryonic Antigen
Stomach Neoplasms
Serum
Blood Vessels
Neoplasms
Multivariate Analysis
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Antigens
Survival
Liver

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer : A mutivariate analysis. / Maehar, Yoshihiko; Kusumoto, Tetsuya; Takahashi, Ikuo; Kakeji, Yoshihiro; Baba, Hideo; Akazawa, Kouhei; Sugimachi, Keizo.

In: Oncology (Switzerland), Vol. 51, No. 3, 01.01.1994, p. 234-237.

Research output: Contribution to journalArticle

Maehar, Yoshihiko ; Kusumoto, Tetsuya ; Takahashi, Ikuo ; Kakeji, Yoshihiro ; Baba, Hideo ; Akazawa, Kouhei ; Sugimachi, Keizo. / Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer : A mutivariate analysis. In: Oncology (Switzerland). 1994 ; Vol. 51, No. 3. pp. 234-237.
@article{8807f388415240e59a70e69d377639ae,
title = "Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer: A mutivariate analysis",
abstract = "Serum carcinoembryonic antigen (CEA) levels were determined preoperatively in 221 patients with well-differentiated gastric cancer. The mean preoperative serum CEA level was 15.9 ± 88.5 ng/ml (1.0-1,133.0 ng/ml) for all patients, and the incidence of an elevated CEA (>5 ng/ml) was 11.8{\%} (26/221). The CEA-positive patients had larger tumors, a more prominent serosal invasion, more frequent lymphatic and vascular involvement, less expansive tumor growth and higher rates of lymph node and hepatic metastases than did the CEA-negative patients. Thus, the CEA-positive patients had a more advanced stage of disease, and 61.5{\%} underwent noncurative resection (vs. 11.3{\%} in CEA-negative patients). The survival rate of the CEA-positive patients was lower than that of the CEA-negative ones (p < 0.01). As the multivariate analysis revealed the preoperative CEA level to be an independent prognostic factor for survival, an assay for this antigen prior to surgery is to be recommended.",
author = "Yoshihiko Maehar and Tetsuya Kusumoto and Ikuo Takahashi and Yoshihiro Kakeji and Hideo Baba and Kouhei Akazawa and Keizo Sugimachi",
year = "1994",
month = "1",
day = "1",
doi = "10.1159/000227340",
language = "English",
volume = "51",
pages = "234--237",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer

T2 - A mutivariate analysis

AU - Maehar, Yoshihiko

AU - Kusumoto, Tetsuya

AU - Takahashi, Ikuo

AU - Kakeji, Yoshihiro

AU - Baba, Hideo

AU - Akazawa, Kouhei

AU - Sugimachi, Keizo

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Serum carcinoembryonic antigen (CEA) levels were determined preoperatively in 221 patients with well-differentiated gastric cancer. The mean preoperative serum CEA level was 15.9 ± 88.5 ng/ml (1.0-1,133.0 ng/ml) for all patients, and the incidence of an elevated CEA (>5 ng/ml) was 11.8% (26/221). The CEA-positive patients had larger tumors, a more prominent serosal invasion, more frequent lymphatic and vascular involvement, less expansive tumor growth and higher rates of lymph node and hepatic metastases than did the CEA-negative patients. Thus, the CEA-positive patients had a more advanced stage of disease, and 61.5% underwent noncurative resection (vs. 11.3% in CEA-negative patients). The survival rate of the CEA-positive patients was lower than that of the CEA-negative ones (p < 0.01). As the multivariate analysis revealed the preoperative CEA level to be an independent prognostic factor for survival, an assay for this antigen prior to surgery is to be recommended.

AB - Serum carcinoembryonic antigen (CEA) levels were determined preoperatively in 221 patients with well-differentiated gastric cancer. The mean preoperative serum CEA level was 15.9 ± 88.5 ng/ml (1.0-1,133.0 ng/ml) for all patients, and the incidence of an elevated CEA (>5 ng/ml) was 11.8% (26/221). The CEA-positive patients had larger tumors, a more prominent serosal invasion, more frequent lymphatic and vascular involvement, less expansive tumor growth and higher rates of lymph node and hepatic metastases than did the CEA-negative patients. Thus, the CEA-positive patients had a more advanced stage of disease, and 61.5% underwent noncurative resection (vs. 11.3% in CEA-negative patients). The survival rate of the CEA-positive patients was lower than that of the CEA-negative ones (p < 0.01). As the multivariate analysis revealed the preoperative CEA level to be an independent prognostic factor for survival, an assay for this antigen prior to surgery is to be recommended.

UR - http://www.scopus.com/inward/record.url?scp=0028273573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028273573&partnerID=8YFLogxK

U2 - 10.1159/000227340

DO - 10.1159/000227340

M3 - Article

C2 - 8196905

AN - SCOPUS:0028273573

VL - 51

SP - 234

EP - 237

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 3

ER -