Predictors of Benign Status in Liver Tumors Under 3 cm in Diameter Misdiagnosed as Hepatocellular Carcinoma

Koichi Kimura, shinji itoh, Takeshi Kurihara, Yoshihiro Yoshida, Huanlin Wang, Norifumi Harimoto, Akihiro Nishie, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The clinical features of benign liver lesions misdiagnosed as hepatocellular carcinoma have not been fully described.

PATIENTS AND METHODS: This study included 187 patients who underwent hepatectomy at the Kyushu University Hospital following a diagnosis of solitary HCC of ≤3 cm in diameter.

RESULTS: Following hepatectomy, 9.6% patients were pathologically diagnosed with benign liver lesions. Univariate analysis showed that patient age ≤67 years, negativity for hepatitis C virus antigen, lesion size ≤1.5 cm, normal level of tumor markers, and absence of increase in tumor size were associated with benign lesions. Patient age ≤67 years and absence of tumor size increase were independent predictors of benign lesions.

CONCLUSION: Benign liver lesions misdiagnosed as HCC were not infrequent, accounting for approximately 10% of resected cases. Age ≤67 years and absence of tumor size increase were independent predictors of benign liver lesions, and may help in the correct diagnosis of HCC.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalAnticancer research
Volume36
Issue number2
Publication statusPublished - Feb 1 2016

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Diagnostic Errors
Hepatocellular Carcinoma
Liver
Hepatectomy
Neoplasms
Hepatitis C Antigens
Tumor Biomarkers
Hepacivirus

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kimura, K., itoh, S., Kurihara, T., Yoshida, Y., Wang, H., Harimoto, N., ... Maehara, Y. (2016). Predictors of Benign Status in Liver Tumors Under 3 cm in Diameter Misdiagnosed as Hepatocellular Carcinoma. Anticancer research, 36(2), 793-797.

Predictors of Benign Status in Liver Tumors Under 3 cm in Diameter Misdiagnosed as Hepatocellular Carcinoma. / Kimura, Koichi; itoh, shinji; Kurihara, Takeshi; Yoshida, Yoshihiro; Wang, Huanlin; Harimoto, Norifumi; Nishie, Akihiro; Shirabe, Ken; Oda, Yoshinao; Maehara, Yoshihiko.

In: Anticancer research, Vol. 36, No. 2, 01.02.2016, p. 793-797.

Research output: Contribution to journalArticle

Kimura, K, itoh, S, Kurihara, T, Yoshida, Y, Wang, H, Harimoto, N, Nishie, A, Shirabe, K, Oda, Y & Maehara, Y 2016, 'Predictors of Benign Status in Liver Tumors Under 3 cm in Diameter Misdiagnosed as Hepatocellular Carcinoma', Anticancer research, vol. 36, no. 2, pp. 793-797.
Kimura, Koichi ; itoh, shinji ; Kurihara, Takeshi ; Yoshida, Yoshihiro ; Wang, Huanlin ; Harimoto, Norifumi ; Nishie, Akihiro ; Shirabe, Ken ; Oda, Yoshinao ; Maehara, Yoshihiko. / Predictors of Benign Status in Liver Tumors Under 3 cm in Diameter Misdiagnosed as Hepatocellular Carcinoma. In: Anticancer research. 2016 ; Vol. 36, No. 2. pp. 793-797.
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AU - Wang, Huanlin

AU - Harimoto, Norifumi

AU - Nishie, Akihiro

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