Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression

Makoto Yawata, Nobuyo Yawata, Karina L. McQueen, Nathalie W. Cheng, Lisbeth A. Guethlein, Raja Rajalingam, Heather G. Shilling, Peter Parham

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Genomic DNA from a panel of 41 healthy unrelated Japanese individuals was typed for the presence or absence of 16 KIR genes and pseudogenes. Only eight different KIR genotypes were found. Group A haplotypes outnumbered group B haplotypes in frequency by approximately 3:1, with individuals having two group A haplotypes accounting for 56% of the panel. The frequency of A haplotypes in the Japanese is higher than that observed in other populations. Flow cytometric comparison of KIR expression in 19 panel members showed considerable diversity in NK cell repertoire, which was also seen within the group of individuals having two A haplotypes. This diversity is likely due to allelic polymorphism in expressed genes of the A haplotype. In comparison to other populations, the Japanese appear less heterogeneous in KIR genotype as assessed by gene content.

Original languageEnglish
Pages (from-to)543-550
Number of pages8
JournalImmunogenetics
Volume54
Issue number8
DOIs
Publication statusPublished - Dec 19 2002
Externally publishedYes

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Natural Killer Cells
Haplotypes
Genotype
Genes
Pseudogenes
Population
DNA

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. / Yawata, Makoto; Yawata, Nobuyo; McQueen, Karina L.; Cheng, Nathalie W.; Guethlein, Lisbeth A.; Rajalingam, Raja; Shilling, Heather G.; Parham, Peter.

In: Immunogenetics, Vol. 54, No. 8, 19.12.2002, p. 543-550.

Research output: Contribution to journalArticle

Yawata, M, Yawata, N, McQueen, KL, Cheng, NW, Guethlein, LA, Rajalingam, R, Shilling, HG & Parham, P 2002, 'Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression', Immunogenetics, vol. 54, no. 8, pp. 543-550. https://doi.org/10.1007/s00251-002-0497-x
Yawata, Makoto ; Yawata, Nobuyo ; McQueen, Karina L. ; Cheng, Nathalie W. ; Guethlein, Lisbeth A. ; Rajalingam, Raja ; Shilling, Heather G. ; Parham, Peter. / Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. In: Immunogenetics. 2002 ; Vol. 54, No. 8. pp. 543-550.
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