Preimplantation-embryo-specific cell cycle regulation is attributed to the low expression level of retinoblastoma protein

Naoki Iwamori, Kunihiko Naito, Koji Sugiura, Hideaki Tojo

Research output: Contribution to journalArticle

21 Citations (Scopus)


It is known that a characteristic of the mammalian preimplantation-embryo-specific cell cycle is the substantially shortened G1-phase, although the regulation mechanisms of the unique cell cycle remain unclear. In the present study, we first examined the presence of retinoblastoma (RB) tumor suppressor gene product throughout mouse preimplantation embryo development and found that the RB expression was down-regulated between the four-cell and morula stages. Furthermore, the overexpression of RB protein in the mouse embryos during this phase inhibited their development significantly. These results suggest that the absence of RB protein contributes to the preimplantation-embryo-specific cell cycle.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalFEBS Letters
Issue number1-3
Publication statusPublished - Aug 28 2002
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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