PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Toshiki Kamano, Noboru Azuma, Atsuo Katami, Junji Tamura, Noburu Sakakibara, Michio Matsumoto, Kazuhiro Mizumoto, Shunji Kitazawa, Yoichi Konishi

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10 Citations (Scopus)

Abstract

Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJapanese Journal of Cancer Research
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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