PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Toshiki Kamano; Noboru Azuma; Atsuo Katami; Junji Tamura; Noburu Sakakibara; Michio Matsumoto; Kazuhiro Mizumoto; Shunji Kitazawa; Yoichi Konishi

doi:10.1111/j.1349-7006.1988.tb00001.x

PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Toshiki Kamano, Noboru Azuma, Atsuo Katami, Junji Tamura, Noburu Sakakibara, Michio Matsumoto, Kazuhiro Mizumoto, Shunji Kitazawa, Yoichi Konishi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	79
Issue number	1
DOIs	https://doi.org/10.1111/j.1349-7006.1988.tb00001.x
Publication status	Published - Jan 1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1988.tb00001.x

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Kamano, T., Azuma, N., Katami, A., Tamura, J., Sakakibara, N., Matsumoto, M., Mizumoto, K., Kitazawa, S., & Konishi, Y. (1988). PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS. Japanese Journal of Cancer Research, 79(1), 1-4. https://doi.org/10.1111/j.1349-7006.1988.tb00001.x

Kamano, T, Azuma, N, Katami, A, Tamura, J, Sakakibara, N, Matsumoto, M, Mizumoto, K, Kitazawa, S & Konishi, Y 1988, 'PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS', Japanese Journal of Cancer Research, vol. 79, no. 1, pp. 1-4. https://doi.org/10.1111/j.1349-7006.1988.tb00001.x

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title = "PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS",

abstract = "Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.",

author = "Toshiki Kamano and Noboru Azuma and Atsuo Katami and Junji Tamura and Noburu Sakakibara and Michio Matsumoto and Kazuhiro Mizumoto and Shunji Kitazawa and Yoichi Konishi",

year = "1988",

month = jan,

doi = "10.1111/j.1349-7006.1988.tb00001.x",

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volume = "79",

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AU - Kamano, Toshiki

AU - Azuma, Noboru

AU - Katami, Atsuo

AU - Tamura, Junji

AU - Sakakibara, Noburu

AU - Matsumoto, Michio

AU - Mizumoto, Kazuhiro

AU - Kitazawa, Shunji

AU - Konishi, Yoichi

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N2 - Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.

AB - Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.

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PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Abstract

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