Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors

Tetsuhide Ito, Masao Tanaka, Hironobu Sasano, Yoshiyuki R. Osamura, Iwao Sasaki, Wataru Kimura, Koji Takano, Takao Obara, Miyuki Ishibashi, Kazuwa Nakao, Ryuichiro Doi, Akira Shimatsu, Toshirou Nishida, Izumi Komoto, Yukio Hirata, Masayuki Imamura, Ken Kawabe, Kazuhiko Nakamura

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Abstract

Background: We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods: Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results: Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions: The incidence of NETsin Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.

Original languageEnglish
Pages (from-to)497-500
Number of pages4
JournalJournal of gastroenterology
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Ito, T., Tanaka, M., Sasano, H., Osamura, Y. R., Sasaki, I., Kimura, W., Takano, K., Obara, T., Ishibashi, M., Nakao, K., Doi, R., Shimatsu, A., Nishida, T., Komoto, I., Hirata, Y., Imamura, M., Kawabe, K., & Nakamura, K. (2007). Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors. Journal of gastroenterology, 42(6), 497-500. https://doi.org/10.1007/s00535-007-2056-6