Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Kanae Konishi, Seiko Sasaki, Shizue Kato, Susumu Ban, Noriaki Washino, Jumboku Kajiwara, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Daisuke Yasutake, Reiko Kishi

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Abstract

Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes. However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies. A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood. Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β=-231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β=-258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β=-24.5 g, 95% CI: -387.4 to -61.5). Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

Original languageEnglish
Pages (from-to)906-913
Number of pages8
JournalEnvironmental Research
Volume109
Issue number7
DOIs
Publication statusPublished - Oct 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

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    Konishi, K., Sasaki, S., Kato, S., Ban, S., Washino, N., Kajiwara, J., Todaka, T., Hirakawa, H., Hori, T., Yasutake, D., & Kishi, R. (2009). Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. Environmental Research, 109(7), 906-913. https://doi.org/10.1016/j.envres.2009.07.010