Prenoids and palmitate: Lipids that control the biological activity of Ras proteins

Kiyoko Kato, Channing J. Der, Janice E. Buss

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Ras proteins can be modified by two types of lipids - an isoprenoid and the fatty acid palmitate. These lipids help the otherwise cytoplasmic Ras protein to interact with the plasma membrane of a cell. The biological consequences of this association between Ras and membranes are dramatic, and can alter a cell's behavior from normal growth into malignancy. The scope and limits of our knowledge of the steps, structures and enzymes involved in this molecular transformation from soluble inactivity to membrane-bound potency are offered below. The prospects of regulating Ras function by controlling its intracellular location provides a tantalizing opportunity to translate research into a novel therapeutic reality.

Original languageEnglish
Pages (from-to)179-188
Number of pages10
JournalSeminars in Cancer Biology
Volume3
Issue number4
Publication statusPublished - Aug 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research

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