Preoperative Chemoradiation Followed by Extensive Pelvic Surgery Improved the Outcome of Posterior Invasive Locally Recurrent Rectal Cancer without Deteriorating Surgical Morbidities: A Retrospective, Single-Institution Analysis

Hisataka Ogawa, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Masakazu Ikenaga, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The main feature of locally recurrent rectal cancer (LRRC) is infiltrating growth; thus, preoperative chemoradiation therapy (preCRT) is recommended to improve patient outcomes. However, no studies have reported the potential impact of preCRT on oncological and surgical outcomes in posterior invasive LRRC (piLRRC) that requires sacrectomy. Methods: Forty-one patients with piLRRC were treated with (n = 25) or without (n = 16) preCRT. Oncological outcomes regarding local re-recurrence-free survival, distant metastasis-free survival, and overall survival (OS) were analyzed. Surgical complications were assessed using the Clavien–Dindo scale. Results: The preCRT group had higher 5-year local re-recurrence-free survival (24.4 vs. 0 %) and OS (46.6 vs. 29.3 %) than the non-preCRT group. Univariate analysis demonstrated that preCRT (p = 0.03) and microlymphatic involvement (p = 0.01) were significantly related to local re-recurrence. Microlymphatic involvement occurred less frequently in the preCRT group than in the non-preCRT group (23.8 vs. 71.4 %; p = 0.01) despite the similarity in primary cancers between groups. Major infectious complications occurred with similar frequency in the preCRT and non-preCRT groups (24 vs. 18.8 %, p = 1). Conclusions: PreCRT significantly benefited oncological outcome without compromising surgical results for piLRRC.

Original languageEnglish
Pages (from-to)4325-4334
Number of pages10
JournalAnnals of Surgical Oncology
Volume22
Issue number13
DOIs
Publication statusPublished - Dec 1 2015
Externally publishedYes

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Rectal Neoplasms
Group Psychotherapy
Morbidity
Survival
Recurrence
Therapeutics
Neoplasm Metastasis
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Preoperative Chemoradiation Followed by Extensive Pelvic Surgery Improved the Outcome of Posterior Invasive Locally Recurrent Rectal Cancer without Deteriorating Surgical Morbidities : A Retrospective, Single-Institution Analysis. / Ogawa, Hisataka; Uemura, Mamoru; Nishimura, Junichi; Hata, Taishi; Ikenaga, Masakazu; Takemasa, Ichiro; Mizushima, Tsunekazu; Ikeda, Masataka; Sekimoto, Mitsugu; Yamamoto, Hirofumi; Doki, Yuichiro; Mori, Masaki.

In: Annals of Surgical Oncology, Vol. 22, No. 13, 01.12.2015, p. 4325-4334.

Research output: Contribution to journalArticle

Ogawa, Hisataka ; Uemura, Mamoru ; Nishimura, Junichi ; Hata, Taishi ; Ikenaga, Masakazu ; Takemasa, Ichiro ; Mizushima, Tsunekazu ; Ikeda, Masataka ; Sekimoto, Mitsugu ; Yamamoto, Hirofumi ; Doki, Yuichiro ; Mori, Masaki. / Preoperative Chemoradiation Followed by Extensive Pelvic Surgery Improved the Outcome of Posterior Invasive Locally Recurrent Rectal Cancer without Deteriorating Surgical Morbidities : A Retrospective, Single-Institution Analysis. In: Annals of Surgical Oncology. 2015 ; Vol. 22, No. 13. pp. 4325-4334.
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abstract = "Purpose: The main feature of locally recurrent rectal cancer (LRRC) is infiltrating growth; thus, preoperative chemoradiation therapy (preCRT) is recommended to improve patient outcomes. However, no studies have reported the potential impact of preCRT on oncological and surgical outcomes in posterior invasive LRRC (piLRRC) that requires sacrectomy. Methods: Forty-one patients with piLRRC were treated with (n = 25) or without (n = 16) preCRT. Oncological outcomes regarding local re-recurrence-free survival, distant metastasis-free survival, and overall survival (OS) were analyzed. Surgical complications were assessed using the Clavien–Dindo scale. Results: The preCRT group had higher 5-year local re-recurrence-free survival (24.4 vs. 0 {\%}) and OS (46.6 vs. 29.3 {\%}) than the non-preCRT group. Univariate analysis demonstrated that preCRT (p = 0.03) and microlymphatic involvement (p = 0.01) were significantly related to local re-recurrence. Microlymphatic involvement occurred less frequently in the preCRT group than in the non-preCRT group (23.8 vs. 71.4 {\%}; p = 0.01) despite the similarity in primary cancers between groups. Major infectious complications occurred with similar frequency in the preCRT and non-preCRT groups (24 vs. 18.8 {\%}, p = 1). Conclusions: PreCRT significantly benefited oncological outcome without compromising surgical results for piLRRC.",
author = "Hisataka Ogawa and Mamoru Uemura and Junichi Nishimura and Taishi Hata and Masakazu Ikenaga and Ichiro Takemasa and Tsunekazu Mizushima and Masataka Ikeda and Mitsugu Sekimoto and Hirofumi Yamamoto and Yuichiro Doki and Masaki Mori",
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T1 - Preoperative Chemoradiation Followed by Extensive Pelvic Surgery Improved the Outcome of Posterior Invasive Locally Recurrent Rectal Cancer without Deteriorating Surgical Morbidities

T2 - A Retrospective, Single-Institution Analysis

AU - Ogawa, Hisataka

AU - Uemura, Mamoru

AU - Nishimura, Junichi

AU - Hata, Taishi

AU - Ikenaga, Masakazu

AU - Takemasa, Ichiro

AU - Mizushima, Tsunekazu

AU - Ikeda, Masataka

AU - Sekimoto, Mitsugu

AU - Yamamoto, Hirofumi

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Purpose: The main feature of locally recurrent rectal cancer (LRRC) is infiltrating growth; thus, preoperative chemoradiation therapy (preCRT) is recommended to improve patient outcomes. However, no studies have reported the potential impact of preCRT on oncological and surgical outcomes in posterior invasive LRRC (piLRRC) that requires sacrectomy. Methods: Forty-one patients with piLRRC were treated with (n = 25) or without (n = 16) preCRT. Oncological outcomes regarding local re-recurrence-free survival, distant metastasis-free survival, and overall survival (OS) were analyzed. Surgical complications were assessed using the Clavien–Dindo scale. Results: The preCRT group had higher 5-year local re-recurrence-free survival (24.4 vs. 0 %) and OS (46.6 vs. 29.3 %) than the non-preCRT group. Univariate analysis demonstrated that preCRT (p = 0.03) and microlymphatic involvement (p = 0.01) were significantly related to local re-recurrence. Microlymphatic involvement occurred less frequently in the preCRT group than in the non-preCRT group (23.8 vs. 71.4 %; p = 0.01) despite the similarity in primary cancers between groups. Major infectious complications occurred with similar frequency in the preCRT and non-preCRT groups (24 vs. 18.8 %, p = 1). Conclusions: PreCRT significantly benefited oncological outcome without compromising surgical results for piLRRC.

AB - Purpose: The main feature of locally recurrent rectal cancer (LRRC) is infiltrating growth; thus, preoperative chemoradiation therapy (preCRT) is recommended to improve patient outcomes. However, no studies have reported the potential impact of preCRT on oncological and surgical outcomes in posterior invasive LRRC (piLRRC) that requires sacrectomy. Methods: Forty-one patients with piLRRC were treated with (n = 25) or without (n = 16) preCRT. Oncological outcomes regarding local re-recurrence-free survival, distant metastasis-free survival, and overall survival (OS) were analyzed. Surgical complications were assessed using the Clavien–Dindo scale. Results: The preCRT group had higher 5-year local re-recurrence-free survival (24.4 vs. 0 %) and OS (46.6 vs. 29.3 %) than the non-preCRT group. Univariate analysis demonstrated that preCRT (p = 0.03) and microlymphatic involvement (p = 0.01) were significantly related to local re-recurrence. Microlymphatic involvement occurred less frequently in the preCRT group than in the non-preCRT group (23.8 vs. 71.4 %; p = 0.01) despite the similarity in primary cancers between groups. Major infectious complications occurred with similar frequency in the preCRT and non-preCRT groups (24 vs. 18.8 %, p = 1). Conclusions: PreCRT significantly benefited oncological outcome without compromising surgical results for piLRRC.

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