Preoperative chemoradiotherapy does not compromise the feasibility of adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma

Hideo Tomihara, Hidetoshi Eguchi, Daisaku Yamada, Kunihito Gotoh, Koichi Kawamoto, Hiroshi Wada, Tadafumi Asaoka, Takehiro Noda, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki

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17 Citations (Scopus)

Abstract

Purpose: Preoperative chemoradiotherapy (CRT) is a novel, emerging treatment strategy for pancreatic ductal adenocarcinoma (PDAC), but it remains unclear whether post-surgery adjuvant chemotherapy is feasible following preoperative CRT. This retrospective study evaluates the feasibility of adjuvant therapy after preoperative CRT. Methods: The subjects of this study were 99 consecutive patients who underwent pancreatectomy for PDAC between January, 2007 and February, 2013 in our hospital. Sixty patients received preoperative CRT: as gemcitabine (GEM) and 40 Gy radiation in 28 (G-CRT group), and as GEM, S-1, and 50.4 Gy radiation in 32 (GS-CRT group). We also evaluated 39 patients who underwent surgery alone (SA group). We investigated adjuvant chemotherapy induction and completion rates and the frequency of adverse events rated ≥grade 3, based on Common Terminology Criteria for Adverse Events (version 4.0) in all three groups. Results: In the G-CRT, GS-CRT, and SA groups, the induction rates were 78 % (22/28), 78 % (25/32), and 72 % (28/39), respectively; completion rates were 86 % (19/22), 88 % (22/25), and 82 % (23/28), respectively; and adverse event frequencies were 36 % (8/22), 28 % (7/25), and 43 % (12/28), respectively. No significant difference was found among the three groups. Conclusion: Preoperative CRT was demonstrated to be safe and did not compromise the feasibility of adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)218-226
Number of pages9
JournalSurgery today
Volume47
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

All Science Journal Classification (ASJC) codes

  • Surgery

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    Tomihara, H., Eguchi, H., Yamada, D., Gotoh, K., Kawamoto, K., Wada, H., Asaoka, T., Noda, T., Takeda, Y., Tanemura, M., Mori, M., & Doki, Y. (2017). Preoperative chemoradiotherapy does not compromise the feasibility of adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma. Surgery today, 47(2), 218-226. https://doi.org/10.1007/s00595-016-1405-6