Preoperative chemoradiotherapy for esophageal cancer: Factors associated with clinical response and postoperative complications

Masaru Morita, Takanobu Masuda, Satoko Okada, Keiji Yoshinaga, Hiroshi Saeki, Eriko Tokunaga, Kazuya Endo, Yasunori Emi, Yoshihiro Kakeji, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Background: The factors associated with the clinical results of preoperative chemoradiotherapy (CRT) for esophageal cancer and its effect on postoperative complications are still unclear. Patients and Methods: The 686 patients with esophageal cancer were classified into 376 who received preoperative CRT (group I) and 310 who received surgery alone (group II). Results: A multivariate analysis for group I patients revealed pathologically complete response to be a favorable prognostic factor. Preoperative use of cisplatin was significantly associated with pathological effect and patients' prognosis. Both pulmonary complications and anastomotic leakage more frequently developed in group I (16.0 and 27.9%) than in group II (10.0%, p<0.05 and 16.5%, p<0.01, respectively). A multivariate analysis revealed preoperative CRT to be an independent factor of postoperative complications. Conclusion: Although preoperative CRT for esophageal cancer may be associated with postoperative complications, a pathologically complete response, which is associated with a cisplatin-based regimen, is critical for improving patient prognosis.

Original languageEnglish
Pages (from-to)2555-2562
Number of pages8
JournalAnticancer research
Volume29
Issue number7
Publication statusPublished - Jul 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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