Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer

Tadahiro Nozoe; Tomohiro Iguchi; Eisuke Adachi; Akito Matsukuma; Takahiro Ezaki

doi:10.1007/s00595-009-4297-x

Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer

Tadahiro Nozoe, Tomohiro Iguchi, Eisuke Adachi, Akito Matsukuma, Takahiro Ezaki

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Purpose. Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients. Methods. We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. Results. The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). Conclusion. Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.

Original language	English
Pages (from-to)	510-513
Number of pages	4
Journal	Surgery today
Volume	41
Issue number	4
DOIs	https://doi.org/10.1007/s00595-009-4297-x
Publication status	Published - Apr 2011

All Science Journal Classification (ASJC) codes

Surgery

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title = "Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer",

abstract = "Purpose. Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients. Methods. We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. Results. The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). Conclusion. Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.",

author = "Tadahiro Nozoe and Tomohiro Iguchi and Eisuke Adachi and Akito Matsukuma and Takahiro Ezaki",

year = "2011",

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doi = "10.1007/s00595-009-4297-x",

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volume = "41",

pages = "510--513",

journal = "Surgery Today",

issn = "0941-1291",

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T1 - Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer

AU - Nozoe, Tadahiro

AU - Iguchi, Tomohiro

AU - Adachi, Eisuke

AU - Matsukuma, Akito

AU - Ezaki, Takahiro

PY - 2011/4

Y1 - 2011/4

N2 - Purpose. Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients. Methods. We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. Results. The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). Conclusion. Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.

AB - Purpose. Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients. Methods. We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. Results. The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). Conclusion. Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.

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